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World J Gastroenterol. Dec 28, 2014; 20(48): 18296-18305
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18296
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18296
Radiobiological characteristics of cancer stem cells from esophageal cancer cell lines
Jian-Lin Wang, Jing-Ping Yu, Zhi-Qiang Sun, Su-Ping Sun, Department of Radiation Oncology, Changzhou Second People’s Hospital Affiliated to Nanjing Medical University, Changzhou 213003, Jiangsu Province, China
Author contributions: Wang JL wrote the manuscript; Yu JP and Sun SP designed and performed the study, analyzed the data and revised the paper; Yu JP, Sun SP and Sun ZQ helped perform a portion of the study.
Supported by Leading Scientific Research Project of the Health Department of Jiangsu Province, China, No. Z201220; Major Project of the Health Department of Changzhou, China, No. ZD201105; and Changzhou Sci-Tech Support Project for Social Development, No. CE20125021
Correspondence to: Su-Ping Sun, PhD, Department of Radiation Oncology, Changzhou Second People’s Hospital Affiliated to Nanjing Medical University, Labor Lane, Changzhou 213003, Jiangsu Province, China. ssp56@126.com
Telephone: +86-519-88118723 Fax: +86-519-88115560
Received: May 4, 2014
Revised: June 28, 2014
Accepted: July 16, 2014
Published online: December 28, 2014
Revised: June 28, 2014
Accepted: July 16, 2014
Published online: December 28, 2014
Core Tip
Core tip: Radiotherapy is one of the major treatments for esophageal squamous cell cancer. However, resistance to radiotherapy is considered to be one of the main reasons for poor prognosis and high mortality rates in patients with esophageal cancers. In recent years, cancer stem cells have received significant attention in cancer research. Cancer stem cells are found tolerant to both radiotherapy and chemotherapy. In this study, we report the isolation of cancer stem cells from human esophageal cancer cell lines KYSE150 and TE1. The biological characteristics of cancer stem cells and their resistance to radiation are discussed.