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World J Gastroenterol. Dec 28, 2014; 20(48): 18151-18164
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18151
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18151
Colorectal carcinogenesis-update and perspectives
Hans Raskov, Speciallægecentret ved Diakonissestiftelsen, 2000 Frederiksberg, Denmark
Hans-Christian Pommergaard, Jakob Burcharth, Jacob Rosenberg, Department of Surgery, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark
Author contributions: All authors contributed to conception and design, critical revision and final approval of the manuscript; and Raskov H wrote the first draft.
Correspondence to: Dr. Hans Raskov, Speciallægecentret ved Diakonissestiftelsen, Peter Bangs vej 3, 2000 Frederiksberg, Denmark. raskov@mail.dk
Telephone: +45-38-868222 Fax: +45-38-868222
Received: June 28, 2014
Revised: August 18, 2014
Accepted: September 29, 2014
Published online: December 28, 2014
Processing time: 191 Days and 12.3 Hours
Revised: August 18, 2014
Accepted: September 29, 2014
Published online: December 28, 2014
Processing time: 191 Days and 12.3 Hours
Core Tip
Core tip: Over the last years the treatment of colorectal cancer has become increasingly dependent on individual patient profiling with regard to both microbiology and genetics. Apart from lifestyle factors and age, genetic predisposition, inflammation and impact of the microbiome appear to be important contributors to malignant transformation in the colon. The review gives an update on colorectal carcinogenesis.