Colorectal carcinogenesis-update and perspectives

doi:10.3748/wjg.v20.i48.18151

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Dec 28, 2014 (publication date) through Apr 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2014; 20(48): 18151-18164
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18151

Colorectal carcinogenesis-update and perspectives

Hans Raskov, Hans-Christian Pommergaard, Jakob Burcharth, Jacob Rosenberg

Hans Raskov, Speciallægecentret ved Diakonissestiftelsen, 2000 Frederiksberg, Denmark

Hans-Christian Pommergaard, Jakob Burcharth, Jacob Rosenberg, Department of Surgery, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark

Author contributions: All authors contributed to conception and design, critical revision and final approval of the manuscript; and Raskov H wrote the first draft.

Correspondence to: Dr. Hans Raskov, Speciallægecentret ved Diakonissestiftelsen, Peter Bangs vej 3, 2000 Frederiksberg, Denmark. raskov@mail.dk

Telephone: +45-38-868222 Fax: +45-38-868222

Received: June 28, 2014
Revised: August 18, 2014
Accepted: September 29, 2014
Published online: December 28, 2014

Core Tip

Core tip: Over the last years the treatment of colorectal cancer has become increasingly dependent on individual patient profiling with regard to both microbiology and genetics. Apart from lifestyle factors and age, genetic predisposition, inflammation and impact of the microbiome appear to be important contributors to malignant transformation in the colon. The review gives an update on colorectal carcinogenesis.