Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2014; 20(48): 18121-18130
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18121
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18121
Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes
Giovanni Tomasello, Emanuele Sinagra, Benedetto Di Trapani, IEMEST, Euro-Mediterranean Institute of Science and Technology, 90139 Palermo, Italy
Pietro Tralongo, Marie Noelle Zeenny, Angelo Leone, Department of Experimental Biomedicine and Clinical Neurosciences, Section of Histology, University of Palermo, 90133 Palermo, Italy
Provvidenza Damiani, AOUP “P Giaccone”, School of Medicine, University of Palermo, 90139 Palermo, Italy
Emanuele Sinagra, Fondazione Istituto S. Raffaele-G. Giglio, Gastroenterology and Endoscopy Unit, Cefalù 90146, Italy
Benedetto Di Trapani, Unit of Surgery, “Clinica Torina”, 90100 Palermo, Italy
Inaya Hajj Hussein, Department of Biomedical Sciences, Oakland University William Beaumont, School of Medicine, Rochester, MI 48309, United States
Marie Noelle Zeenny, Abdo Jurjus, Deparment of Anatomy, Cell Biology and Physiology, American University of Beirut, Beirut 1107-2020, Lebanon
Author contributions: Tomasello G put the overall plan of the review; Tralongo P did the literature search; Damiani P did also the literature search; Sinagra E wrote the first draft; Di Trapani B reviewed the first draft and presented a second draft; Zeenny MN worked on the reference section; Hajj Hussein I reviewed the second draft in particular the microbial flora component and added the section on dysiosis and diet; Jurjus A reviewed the second draft and the final draft submitted; Leone A along with Tomasello G were the initiators and coordinators of the work.
Supported by MIUR EX 60%
Correspondence to: Angelo Leone, DDS PGCAPHE, Department of Experimental Biomedicine and Clinical Neurosciences, Section of Histology, University of Palermo, Via del vespro 129, 90127 Palermo, Italy. angelo.leone@unipa.it
Telephone: +39-91-6553581 Fax: +39-91-6553586
Received: June 6, 2014
Revised: August 10, 2014
Accepted: September 29, 2014
Published online: December 28, 2014
Revised: August 10, 2014
Accepted: September 29, 2014
Published online: December 28, 2014
Core Tip
Core tip: Dysbiosis could be the common denominator of inflammatory bowel disease (IBD) and colorectal cancer. A well balanced gut microbiota promotes the health of colocytes through the production of important compounds and the correct modulation of immune system. Qualitative and quantitative modifications in the bacterial composition are responsible of changes in the biochemistry and in the cell cycle of colocytes. The aim of this work is to focus on the molecular mechanisms that connect dysbiosis, IBD and colorectal cancer. Experimental studies are oriented towards the discovery of new probiotic-based therapies for the treatment and prevention of inflammatory and carcinogenetic processes.