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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2014; 20(47): 17976-17984
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17976
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17976
Cost-effectiveness analysis of colon cancer treatments from MOSIAC and No. 16968 trials
Feng Wen, Peng-Fei Zhang, Rui-Lei Tang, Qiu Li, Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Ke Yao, Department of Biostatistics, West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan Province, China
Ze-Dong Du, Department of Oncology, 363 Hospital, Chengdu 610041, Sichuan Province, China
Xiao-Feng He, Department of Medical Oncology, First People’s Hospital of Longquanyi District, Chengdu 610041, Sichuan Province, China
Author contributions: Li Q and Wen F performed the majority of the research, including study design, data collection, data analysis and interpretation; they also wrote the manuscript; Yao K and Zhang PF provided analytical tools and edited the manuscript; Du ZD and He XF collected the related material; Tang RL helped to complete the tables and figures; all the authors gave their final approval to the manuscript.
Supported by National Natural Science Foundation of China, No. 81071862
Correspondence to: Qiu Li, MD, PhD, Professor, Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Guoxuexiang 37, Wuhou District, Chengdu 610041, Sichuan Province, China. fbqiu9@163.com
Telephone: +86-28-85423262 Fax: +86-28-85423609
Received: April 21, 2014
Revised: July 5, 2014
Accepted: August 13, 2014
Published online: December 21, 2014
Processing time: 243 Days and 6.2 Hours
Revised: July 5, 2014
Accepted: August 13, 2014
Published online: December 21, 2014
Processing time: 243 Days and 6.2 Hours
Core Tip
Core tip: Notably, patients with stage III colon cancer are recommended to receive either XELOX or FOLFOX4 as adjuvant therapy. However, there has not been a cost-effectiveness analysis of these two regimens. This study compared XELOX and FOLFOX4 as adjuvant chemotherapy for patients with colon cancer based on the MOSAIC and No. 16968 trails from a Chinese cost-effectiveness perspective. Our results demonstrated that XELOX was a more cost-effective treatment for adjuvant chemotherapy of colon cancer in China.