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World J Gastroenterol. Dec 21, 2014; 20(47): 17727-17736
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17727
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17727
Impact of the gut microbiota on rodent models of human disease
Axel Kornerup Hansen, Camilla Hartmann Friis Hansen, Section of Experimental Animal Models, Department of Veterinary Disease Biology, University of Copenhagen, 1871 Frederiksberg, Denmark
Lukasz Krych, Dennis Sandris Nielsen, Department of Food Science, Faculty of Sciences, University of Copenhagen, 1958 Frederiksberg, Denmark
Author contributions: All authors contributed to this paper equally.
Correspondence to: Axel Kornerup Hansen, Professor, DVSc, DVM, DipECLAM, Section of Experimental Animal Models, Department of Veterinary Disease Biology, University of Copenhagen, 57 Thorvaldsensvej, 1871 Frederiksberg, Denmark. akh@sund.ku.dk
Telephone: +45-353-32726 Fax: +45-353-32755
Received: February 27, 2014
Revised: September 30, 2014
Accepted: November 18, 2014
Published online: December 21, 2014
Revised: September 30, 2014
Accepted: November 18, 2014
Published online: December 21, 2014
Core Tip
Core tip: Full characterization of the gut microbiota of animal models has revealed that animal models within different research areas, such as diabetes, obesity, cancer, allergy, behavior and colitis, are highly affected by their gut microbiota. The mechanistic aspects are not clear; however, the impact of the microbiota on animal models is of a magnitude that cannot be ignored in future research. Therefore, either models with specific microbiota must be developed, or the microbiota must be characterized in individual studies and incorporated into data evaluation.