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World J Gastroenterol. Dec 21, 2014; 20(47): 17693-17698
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17693
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17693
Genetic polymorphism in pathogenesis of irritable bowel syndrome
Cynthia KY Cheung, Justin CY Wu, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
Author contributions: Cheung CKY and Wu JCY equally contributed to this paper.
Correspondence to: Justin CY Wu, Professor, Institute of Digestive Disease, The Chinese University of Hong Kong, 9/F, Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong, China. justinwu@cuhk.edu.hk
Telephone: +852-26323593 Fax: +852-26373852
Received: June 24, 2014
Revised: September 22, 2014
Accepted: December 1, 2014
Published online: December 21, 2014
Processing time: 179 Days and 2.2 Hours
Revised: September 22, 2014
Accepted: December 1, 2014
Published online: December 21, 2014
Processing time: 179 Days and 2.2 Hours
Core Tip
Core tip: Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS. Although a number of IBS- related genes have been identified, the majority of the identified genes required further validation as each of them may only contribute to the pathophysiology in 1%-5% in patients with functional gastrointestinal disorders.