Prospective Study
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World J Gastroenterol. Dec 14, 2014; 20(46): 17568-17577
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17568
Upper-gastrointestinal bleeding secondary to peptic ulcer disease: Incidence and outcomes
Samuel Quan, Alexandra Frolkis, Kaylee Milne, Natalie Molodecky, Hong Yang, Elijah Dixon, Chad G Ball, Robert P Myers, Subrata Ghosh, Robert Hilsden, Sander Veldhuyzen van Zanten, Gilaad G Kaplan
Samuel Quan, Alexandra Frolkis, Kaylee Milne, Natalie Molodecky, Hong Yang, Robert P Myers, Subrata Ghosh, Robert Hilsden, Gilaad G Kaplan, Departments of Medicine, University of Calgary, Calgary T2N-4N1, Alberta, Canada
Samuel Quan, Alexandra Frolkis, Kaylee Milne, Natalie Molodecky, Hong Yang, Robert P Myers, Robert Hilsden, Gilaad G Kaplan, Departments of Community Health Sciences, Calgary T2N-4N1, Alberta, Canada
Elijah Dixon, Chad G Ball, Departments of Surgery, University of Calgary, Calgary T2N-4N1, Alberta, Canada
Sander Veldhuyzen van Zanten, Department of Medicine, University of Alberta, Edmonton T6G-2R7, Alberta, Canada
Author contributions: Quan S and Kaplan GG, participated in conceiving the study idea and developing the study design; Yang H, Hilsden R and Kaplan GG prepared the data; Frolkis A, Molodecky N and Yang H analyzed the data; Kaplan GG supervised the data analysis; Quan S, Frolkis A, Milne K, Molodecky N, Dixon E, Ball CG, Myers RP, Ghosh S, Hilsden R, van Zanten SV and Kaplan GG contributed to the interpretation of the data and results; Quan S and Kaplan GG wrote the manuscript; Frolkis A, Milne K, Molodecky N, Yang H, Dixon E, Ball CG, Myers RP, Ghosh S, Hilsden R and van Zanten SV edited the manuscript for intellectual content; Kaplan GG confirms that he has had full access to all the data in the study and had final responsibility for the decision to submit for publication.
Supported by Summer studentships (2010, 2011, and 2012) by Alberta Innovates - Health Solutions. Alexandra Frolkis is funded by an Alberta Innovates - Health Solutions studentship to Samuel Quan; A New Investigator Award from the Canadian Institute of Health Research and a Clinical Investigator Award from Alberta Innovates - Health Solutions to Dr. Myers; A New Investigator Award from the Canadian Institute of Health Research and a Population Health Investigator Award from Alberta Innovates - Health Solutions to Dr. Kaplan
Correspondence to: Gilaad G Kaplan, MD, MPH, FRCPC, Associate Professor, Departments of Medicine, University of Calgary, 3280 Hospital Drive NW, Room 6D56, Calgary, AB T2N-4N1, Canada. ggkaplan@ucalgary.ca
Telephone: +1-403-5925015 Fax: +1-403-5925090
Received: March 2, 2013
Revised: May 15, 2014
Accepted: May 26, 2014
Published online: December 14, 2014
Processing time: 291 Days and 10.7 Hours
Core Tip

Core tip: In our population-based study the overall risk of surgery, in-hospital mortality, and 30-d readmission for hospitalized upper gastrointestinal bleeding (UGIB) secondary to peptic ulcer disease (PUD) was 4.3%, 8.5%, and 4.7%, respectively. Duodenal ulcers had a worse prognosis than gastric ulcers. Readmission was more common among rural residents, which might be due to decreased access to resources or practice differences between urban and rural centers. Interventional radiology was uncommonly utilized (0.6%) and limited to urban centers, but prevented surgery in 3/4 of patients. These findings suggest that greater access to medical services may improve outcomes for UGIB secondary to PUD.