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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2014; 20(45): 17254-17259
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17254
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17254
Blue rubber bleb nevus syndrome: A case report and literature review
Xue-Li Jin, Xi-Bin Xiao, Lian-Sheng Huang, Xiao-Ying Zhao, Department of Hematology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Zhao-Hong Wang, Department of Surgical Oncology, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, Zhejiang Province, China
Author contributions: Jin XL wrote the manuscript; Jin XL, Xiao XB and Huang LS managed the patient; Jin XL and Wang ZH collected the patient’s clinical data and figures; and Zhao XY participated in the manuscript writing.
Correspondence to: Xiao-Ying Zhao, Professor, Department of Hematology, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jie-Fang Road, Hangzhou 310009, Zhejiang Province, China. zrxz@zju.edu.cn
Telephone: +86-571-87783672 Fax: +86-571-87022776
Received: March 20, 2014
Revised: April 21, 2014
Accepted: July 24, 2014
Published online: December 7, 2014
Revised: April 21, 2014
Accepted: July 24, 2014
Published online: December 7, 2014
Core Tip
Core tip: We present a case of blue rubber bleb nevus syndrome (BRBNS). This is the 12th Chinese patient and the first female from the Chinese Mainland reported in the English literature. BRBNS is a rare disease characterized by multiple venous malformations and hemangiomas in the skin and visceral organs. The most common symptoms are gastrointestinal bleeding and secondary iron deficiency anemia. We summarize the epidemiology, clinical manifestations, diagnosis, differential diagnosis and therapies of the disease. In a patient with gastrointestinal bleeding and multiple hemangiomas, a diagnosis of BRBNS should be considered and a systemic examination is necessary. An early diagnosis will improve the patient’s quality of life.