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World J Gastroenterol. Dec 7, 2014; 20(45): 17127-17131
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17127
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17127
Proton pump inhibitor administration delays rebleeding after endoscopic gastric variceal obturation
Won Seok Jang, Hyun Phil Shin, Joung Il Lee, Kwang Ro Joo, Jae Myung Cha, Jung Won Jeon, Jun Uk Lim, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul 130-701, South Korea
Author contributions: Jang WS and Shin HP designed the study and wrote the manuscript; Lee JI contributed to the design and editing of the study; Joo KR and Cha JM provided analytical tools; Jeon JW and Lim JU collected the study material and edited the manuscript; all authors approved the final manuscript.
Correspondence to: Hyun Phil Shin, MD, PhD, Department of Internal Medicine, College of Medicine, Kyung Hee University, Kyung Hee University Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul 130-701, South Korea. megadoctor@medimail.co.kr
Telephone: +82-2-4408149 Fax: +82-2-4408150
Received: February 13, 2014
Revised: May 24, 2014
Accepted: July 24, 2014
Published online: December 7, 2014
Processing time: 299 Days and 19.7 Hours
Revised: May 24, 2014
Accepted: July 24, 2014
Published online: December 7, 2014
Processing time: 299 Days and 19.7 Hours
Core Tip
Core tip: Endoscopic variceal obturation (EVO) with N-butyl-2 cyanoacrylate is a first-line treatment for gastric variceal bleeding. Although proton pump inhibitors (PPIs) are administered to decrease the adverse effects of endoscopic variceal ligation, their effects following EVO for gastric varices are unclear. In this study, patients who received PPI therapy had a longer rebleeding interval after EVO with N-butyl-2-cyanoacrylate, suggesting it has beneficial effects for gastric variceal bleeding.