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World J Gastroenterol. Dec 7, 2014; 20(45): 17037-17048
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17037
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17037
Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer
Ru Chen, Sheng Pan, Lisa A Lai, David A Crispin, Teresa A Brentnall, Department of Medicine, University of Washington, Seattle, WA 98195, United States
Keith Lai, Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Mary P Bronner, Division of Anatomic Pathology, University of Utah, Salt Lake City, UT 84108, United States
Author contributions: Chen R, Pan S and Brentnall TA designed the research; Lai LA and Crispin DA performed the experiments; Chen R, Pan S, Lai K, Bronner MP and Brentnall TA analyzed the data; Chen R, Pan S, Lai LA and Brentnall TA wrote the manuscript; Bronner MP and Brentnall TA contributed equally to this manuscript.
Supported by Grants from National Institutes of Health, No. R21CA164548; and from Crohn’s and Colitis Foundation of America
Correspondence to: Ru Chen, PhD, Department of Medicine, University of Washington, Schmitz Hall, Box 355840, Seattle, WA 98195, United States. ruchen@u.washington.edu
Telephone: +1-206-2214109 Fax: +1-206-6859478
Received: November 28, 2013
Revised: February 21, 2014
Accepted: April 2, 2014
Published online: December 7, 2014
Processing time: 377 Days and 12 Hours
Revised: February 21, 2014
Accepted: April 2, 2014
Published online: December 7, 2014
Processing time: 377 Days and 12 Hours
Core Tip
Core tip: Chronic ulcerative colitis (UC) is an inflammatory bowel disease that predisposes to colorectal cancer. Our study showed that up-regulation of tumor necrosis factor receptor-associated protein 1 (TRAP1) occurred early in the neoplastic progression of UC associated cancer: it was present in both the dysplastic and non-dysplastic tissues of UC progressors. Our study further showed that the increase of TRAP1 expression in UC progressors positively correlated with the degree of inflammation in the colorectal cancer tissues, which could be related to the increased oxidation present in the colonic mucosa from UC progressors. TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer.