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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2014; 20(45): 16902-16912
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.16902
Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.16902
Hormonal protection in acute pancreatitis by ghrelin, leptin and melatonin
Jolanta Jaworek, Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Collegium Medicum, 31-125 Kraków, Poland
Stanisław Jan Konturek, Chair of Physiology, Medical Faculty, Jagiellonian University Collegim Medicum, 31-125 Kraków, Poland
Author contributions: Both authors contributed to this manuscript and approved the final version.
Correspondence to: Jolanta Jaworek, MD, PhD, Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Collegium Medicum, Michałowskiego str. 12, 31-125 Kraków, Poland. mpjawore@cyf-kr.edu.pl
Telephone: +48-12-6343397 Fax: +48-12-6343397
Received: March 4, 2014
Revised: April 15, 2014
Accepted: August 13, 2014
Published online: December 7, 2014
Processing time: 280 Days and 17 Hours
Revised: April 15, 2014
Accepted: August 13, 2014
Published online: December 7, 2014
Processing time: 280 Days and 17 Hours
Core Tip
Core tip: The pathogenesis of acute pancreatitis is not clear and treatment of this disease is unspecific. Since the severe form of acute pancreatitis often leads to death or to pancreatic insufficiency, the understanding of the mechanisms involved in pancreatic protection appears to be an important problem. Experimental data have shown that pancreatitis severity could be attenuated by various hormones. Herein, we review the results of our research studies and others, as well as data from clinical observations concerning the protective effects of ghrelin, leptin and melatonin on acute pancreatitis. We also present the hypothetical mechanisms responsible for the beneficial influence of these substances on pancreatic inflammation.