Hepatic clearance measured with 99mTc-GSA single-photon emission computed tomography to estimate liver fibrosis

doi:10.3748/wjg.v20.i44.16714

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Nov 28, 2014 (publication date) through Nov 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Nov 28, 2014; 20(44): 16714-16720
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16714

Hepatic clearance measured with ^99mTc-GSA single-photon emission computed tomography to estimate liver fibrosis

Masahiko Taniguchi, Atsutaka Okizaki, Kenji Watanabe, Koji Imai, Koichiro Uchida, Takahiro Einama, Noriyuki Shuke, Naoyuki Miyokawa, Hiroyuki Furukawa

Masahiko Taniguchi, Kenji Watanabe, Koji Imai, Koichiro Uchida, Takahiro Einama, Hiroyuki Furukawa, Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, Asahikawa 078-8510, Japan

Atsutaka Okizaki, Noriyuki Shuke, Department of Radiology, Asahikawa Medical College, Asahikawa 078-8510, Japan

Naoyuki Miyokawa, Department of Pathology, Asahikawa Medical College, Asahikawa 078-8510, Japan

Author contributions: Taniguchi M designed the study and wrote the manuscript; Okizaki A, Watanabe K, Einama T, Uchida K, Imai K and Miyokawa N collected the data; Taniguchi M and Okizaki A analyzed the data; and Shuke N and Furukawa H revised the manuscript.

Correspondence to: Masahiko Taniguchi, MD, Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical College, 2-1, Midorigaoka-Higashi, Asahikawa 078-8510, Japan. m-tani@asahikawa-med.ac.jp

Telephone: +81-166-682503 Fax: +81-166-682193

Received: February 12, 2014
Revised: June 3, 2014
Accepted: July 22, 2014
Published online: November 28, 2014

Core Tip

Core tip: This retrospective study evaluated the clinical utility of hepatic clearance measured with technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl human serum albumin (^99mTc-GSA) single-photon emission computed tomography for estimating the degree of liver fibrosis. We demonstrated that ^99mTc-GSA hepatic clearance showed strong correlations with the degree of liver fibrosis and conventional liver function tests. It is a reliable index for assessing severe liver fibrosis. We believe that this quantitative index can yield a more accurate estimation of liver fibrosis compared with currently used measures before hepatectomy for hepatobiliary surgeons.