Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2014; 20(44): 16702-16706
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16702
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16702
Decreased expression of gastrokine 1 in gastric mucosa of gastric cancer patients
Xiao-Yan Guo, Lei Dong, Bin Qin, Jiong Jiang, A-Meng Shi, Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710003, Shaanxi Province, China
Author contributions: Guo XY and Qin B performed the majority of experiments; Guo XY wrote the manuscript; Dong L designed the study; Jiang J and Shi AM collected all the human tissues.
Correspondence to: Xiao-Yan Guo, MD, Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an 710003, Shaanxi Province, China. gxiaoyan_2000@163.com
Telephone: +86-29-87679660 Fax: +86-29-87679660
Received: April 7, 2014
Revised: August 3, 2014
Accepted: September 18, 2014
Published online: November 28, 2014
Revised: August 3, 2014
Accepted: September 18, 2014
Published online: November 28, 2014
Core Tip
Core tip: The current study evaluated the expression of gastrokine 1 (GKN1) in normal gastric mucosa, gastric cancer tissues and gastric lesions. We found that GKN1 expression was decreased in gastric cancer tissues. Furthermore, low expression of GKN1 was particularly associated with diffuse types of gastric cancer patients. The role of GKN1 in gastric carcinogenesis requires further investigation.