Alleviated mucosal and neuronal damage in a rat model of Crohn&rsquo;s disease

doi:10.3748/wjg.v20.i44.16690

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 20, Issue 44

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6607)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-5) series, Tables (1-1) series.

Item

Count

PDF

331

WORD

252

HTML

4019

Figures (1-5)

154

Tables (1-1)

119

Sum=4875

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

898

Download

834

Sum=1732

Nov 28, 2014 (publication date) through Apr 29, 2024

Times Cited of This Article

Times Cited (7)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Research Report

World J Gastroenterol. Nov 28, 2014; 20(44): 16690-16697
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16690

Alleviated mucosal and neuronal damage in a rat model of Crohn’s disease

Petra Talapka, Lajos István Nagy, Alexandra Pál, Marietta Zita Poles, Anikó Berkó, Mária Bagyánszki, László Géza Puskás, Éva Fekete, Nikolett Bódi

Petra Talapka, Alexandra Pál, Marietta Zita Poles, Anikó Berkó, Mária Bagyánszki, Éva Fekete, Nikolett Bódi, Department of Physiology, Anatomy and Neuroscience, Faculty of Sciences and Informatics, University of Szeged, H-6726 Szeged, Hungary

Lajos István Nagy, László Géza Puskás, Avidin Ltd., Alsó kikötő sor 11, H-6726 Szeged, Hungary

Author contributions: Talapka P performed the majority of experiments and analyzed the data; Nagy LI and Berkó A performed the molecular investigations; Pál A, Poles MZ and Bódi N participated equally in treatment of animals; Bagyánszki M, Puskás LG, Fekete É and Bódi N designed and coordinated the research; Talapka P, Fekete É and Bódi N wrote the paper.

Supported by Hungarian Scientific Research Fund, No. OTKA PD 108309 (to Bódi N); and European Union and the State of Hungary; co-financed by the European Social Fund in the framework of TÁMOP 4.2.4.A/2-11/1-2012-0001 “National Excellence Program”

Correspondence to: Nikolett Bódi, PhD, Senior Lecturer, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary. bodiniki85@gmail.com

Telephone: +36-62-544149 Fax: +36-62-544291

Received: March 27, 2014
Revised: May 27, 2014
Accepted: July 22, 2014
Published online: November 28, 2014

Core Tip

Core tip: We report our first results derived from a newly developed rat model with chronic experimental colitis allowed us to modelling the recurring periods of recrudescence and remission in Crohn’s disease. Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Repetitive recurrent inflammations (RRI) were mimicked by repeated administrations of TNBS. This study demonstrates for the first time that experimentally provoked RRI develop preconditioning effect by speeding up mucosal healing and restoring myenteric neuronal injury. Decreased severity of gut inflammation after repeated TNBS treatments might be associated with the persistent up-regulation of heme-oxygenase 1 messenger RNA expression.