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World J Gastroenterol. Nov 28, 2014; 20(44): 16665-16673
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16665
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16665
Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53
Hsi-Hsien Hsu, Division of Colorectal Surgery, Mackay Memorial Hospital, Taipei 251, Taiwan
Hsi-Hsien Hsu, Mackay Junior College of Medicine, Nursing and Management, Taipei 112, Taiwan
Wei-Wen Kuo, Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan
Da-Tong Ju, Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Yu-Lan Yeh, Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan
Chuan-Chou Tu, Division of Chest Medicine, Department of internal Medicine, Armed Force Taichung General Hospital, Taichung 411, Taiwan
Ying-Lan Tsai, National Taiwan Sport University, Athletic Training and Health Department, Taoyuan 333, Taiwan
Chia-Yao Shen, Department of Nursing, MeiHo University, Pingtung 912, Taiwan
Sheng-Huang Chang, Tsao-Tun Psychiatric Center, Department of Health, Executive Yuan, Nantou 542, Taiwan
Li-Chin Chung, Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
Chih-Yang Huang, Graduate Institute of Chinese Medical Science, China Medical University, Taichung 404, Taiwan
Chih-Yang Huang, Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan
Chih-Yang Huang, Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan
Author contributions: All authors contributed to the manuscript.
Supported by Taiwan Department of Health Clinical Trial and Research Center of Excellence No. MOHW103-TDU-B-212-113002
Correspondence to: Chih-Yang Huang, PhD, Graduate Institute of Basic Medical Science, China Medical University, No. 91 Hsueh-Shih Road, Taichung 404, Taiwan. cyhuang@mail.cmu.edu.tw
Telephone: +886-4-22053366-3313 Fax: +886-4-22032295
Received: February 19, 2014
Revised: April 10, 2014
Accepted: June 21, 2014
Published online: November 28, 2014
Revised: April 10, 2014
Accepted: June 21, 2014
Published online: November 28, 2014
Core Tip
Core tip: The present study is to investigate the effects of 17β-estradiol via estrogen receptors or directly administration of ERs agonist on the development of human colorectal cancer, and to elucidate whether the effect was regulated by tumor suppressor gene p53. Here, our results showed that 17β-estradiol and/or ERs agonist treatment in human LoVo colorectal cancer cells could active p53, then up-regulated p21 and p27 protein levels, subsequently inhibited downstream target gene, cyclin D1, which regulated the cell proliferation.