Park JM, Lee S, Chung MK, Kwon SH, Kim EH, Ko KH, Kwon CI, Hahm KB. Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature. World J Gastroenterol 2014; 20(44): 16570-16581 [PMID: 25469025 DOI: 10.3748/wjg.v20.i44.16570]
Corresponding Author of This Article
Ki Baik Hahm, MD, PhD, Professor, CHA Cancer Prevention Research Center, CHA University, 605 Yeoksam 1-dong, Gangnam-gu, Seoul 135-081, South Korea. hahmkb@cha.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 28, 2014; 20(44): 16570-16581 Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16570
Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature
Jong-Min Park, Sooyeon Lee, Mi Kyung Chung, Sung-Hun Kwon, Eun-Hee Kim, Kwang Hyun Ko, Chang Il Kwon, Ki Baik Hahm
Jong-Min Park, Sooyeon Lee, Mi Kyung Chung, Sung-Hun Kwon, Eun-Hee Kim, Ki Baik Hahm, CHA Cancer Prevention Research Center, CHA University, Seoul 135-081, South Korea
Kwang Hyun Ko, Chang Il Kwon, Ki Baik Hahm, Digestive Disease Center, CHA University Bundang Medical Center, Seongnam 463-838, South Korea
Author contributions: Park JM and Lee S performed the majority of experiments; Chung MK, Kwon SH and Ko KH contributed new reagents or analytic tools for this work; Kim EH, Kwon CI and Hahm KB designed the study; Park JM and Hahm KB analyzed the data and wrote the manuscript.
Supported by The 2013 grant from the Korean Society of Ginseng funded by Korean Ginseng Cooperation
Correspondence to: Ki Baik Hahm, MD, PhD, Professor, CHA Cancer Prevention Research Center, CHA University, 605 Yeoksam 1-dong, Gangnam-gu, Seoul 135-081, South Korea. hahmkb@cha.ac.kr
Telephone: +82-2-34682869 Fax: +82-2-34682868
Received: January 8, 2014 Revised: March 10, 2014 Accepted: May 12, 2014 Published online: November 28, 2014 Processing time: 327 Days and 23.4 Hours
Core Tip
Core tip: In this review, the paradigm shift regarding the development of phytoceuticals and antioxidants is introduced following a comprehensive description of newer information pertaining to the pathogenesis of pancreatitis. Several animal models are discussed with regard to their role in efforts to develop efficient strategies against pancreatitis. Subsequently, newer therapeutic options with an emphasis on nutrients and phytoceuticals are reviewed. Further discussion also focuses on the promise of studies evaluating the effects of antioxidants/phytoceuticals in pancreatitis, the disappointing nature of translation of these agents to clinical settings, and the expected research advances that may support the use of antioxidative phytoceuticals in the treatment of pancreatitis.
