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World J Gastroenterol. Nov 28, 2014; 20(44): 16518-16528
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16518
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16518
Effect of probiotic administration on the intestinal microbiota, current knowledge and potential applications
Alejandra de Moreno de LeBlanc, Jean Guy LeBlanc, Centro de Referencia para Lactobacilos, San Miguel de Tucuman, Tucumán T4000ILC, Argentina
Author contributions: de Moreno de LeBlanc A and LeBlanc JG contributed equally to this work; both authors performed the bibliographic search and wrote the paper.
Supported by Consejo Nacional de Investigaciones Científicas y Técnicas No. CONICET and the Agencia Nacional de Promoción Científica y Tecnológica No. ANPCyT
Correspondence to: Dr. Alejandra de Moreno de LeBlanc, Centro de Referencia para Lactobacilos, San Miguel de Tucumán, Chacabuco 145, Tucumán T4000ILC, Argentina. demoreno@cerela.org.ar
Telephone: +54-381-4310465 Fax: +54-381-4005600
Received: March 7, 2014
Revised: April 22, 2014
Accepted: August 13, 2014
Published online: November 28, 2014
Processing time: 269 Days and 12.4 Hours
Revised: April 22, 2014
Accepted: August 13, 2014
Published online: November 28, 2014
Processing time: 269 Days and 12.4 Hours
Core Tip
Core tip: The human body is colonized by a wide variety of microorganisms that constantly interact with the host. The dysbiosis of the gut microbiota is considered to be one of the most important contributing factors in the development of gastrointestinal as well as systemic diseases. Many studies relate the health promoting properties of probiotic microorganisms with a beneficial balance of the host intestinal microbiota. In this review, the association of the human gut microbiota and human health will be discussed along with the benefits that probiotics can confer on this symbiotic activity and on the prevention or treatment of associated diseases.