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World J Gastroenterol. Nov 28, 2014; 20(44): 16498-16517
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16498
Published online Nov 28, 2014. doi: 10.3748/wjg.v20.i44.16498
Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health
Connie WY Ha, Andrew J Holmes, School of Molecular Bioscience and Charles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia
Yan Y Lam, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States
Author contributions: All authors contributed to this manuscript.
Correspondence to: Andrew J Holmes, PhD, School of Molecular Bioscience and Charles Perkins Centre, The University of Sydney, Building D17, Johns Hopkins Drive, Camperdown, NSW 2006, Australia. andrew.holmes@sydney.edu.au
Telephone: +61-2-93512530
Received: March 29, 2014
Revised: June 26, 2014
Accepted: August 13, 2014
Published online: November 28, 2014
Revised: June 26, 2014
Accepted: August 13, 2014
Published online: November 28, 2014
Core Tip
Core tip: The development of dysbiosis is driven by multiple factors. These include selective pressures imposed on the microbial community by the diet composition and feedback effects that involve either diet-host interaction or diet-microbiome-host interaction. The role of microbial signals in dysbiosis is well established but the involvement of host feedback mechanisms in aberrant host-microbial interactions is an under-appreciated part of disease progression. New opportunities to intervene in diseases of dysbiosis can result from targeting these distinct processes. These include stimulation of the host ability to self-regulate and blocking of deleterious host responses.