Case Report
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2014; 20(42): 15931-15936
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15931
Delayed hypersensitivity reaction resulting in maculopapular-type eruption due to entecavir in the treatment of chronic hepatitis B
Jeong Tae Kim, Hye Won Jeong, Ki Hwa Choi, Tae Young Yoon, Nohyun Sung, Young Ki Choi, Eun Ha Kim, Hee Bok Chae
Jeong Tae Kim, Hye Won Jeong, Hee Bok Chae, Department of Internal Medicine, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 361-711, South Korea
Ki Hwa Choi, Tae Young Yoon, Department of Dermatology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 361-711, South Korea
Nohyun Sung, Department of Pathology, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 361-711, South Korea
Young Ki Choi, Eun Ha Kim, Department of Microbiology, College of Medicine and Medical Research Institute, Chunguk National University, Cheongju 361-711, South Korea
Author contributions: Kim JT collected the data and drafted the manuscript; Jeong HW assisted in generating the figures and drafting the manuscript; Chae HB designed the study and revised the manuscript for intellectual content; Choi KH and Yoon TY provided the dermatology images and revised the dermatological content of the manuscript; Sung N provided the microscope images and revised the pathological content of the manuscript; Choi YK and Kim EH performed the immunological experimentation on patient samples.
Supported by Grant from the Chungbuk National University Hospital (2013)
Correspondence to: Hee Bok Chae, MD, Department of Internal Medicine, College of Medicine and Medical Research Institute, Chungbuk National University, 52 Naesudong-ro, Heungdeok-gu, Cheongju 361-711, South Korea. hbhcae@chungbuk.ac.kr
Telephone: +82-43-2696363 Fax: +82-43-2733252
Received: February 23, 2014
Revised: May 25, 2014
Accepted: July 24, 2014
Published online: November 14, 2014
Processing time: 267 Days and 15.1 Hours
Core Tip

Core tip: A potent efficacy and good overall safety profile has supported the rapid establishment of entecavir as a frequently prescribed antiviral nucleoside for treatment of chronic hepatitis B (CHB). Among the adverse drug reactions that have been reported in CHB patients, allergic dermatitis is especially rare, with only two cases in the literature to date. This report describes a pathologically and immunologically evidenced case of entecavir (ETV)-induced type IV delayed hypersensitivity reaction, which resolved upon ETV withdrawal.