Kim HG, Kim JM, Han JM, Lee JS, Choi MK, Lee DS, Park YH, Son CG. Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model. World J Gastroenterol 2014; 20(42): 15703-15714 [PMID: 25400454 DOI: 10.3748/wjg.v20.i42.15703]
Corresponding Author of This Article
Chang-Gue Son, MD, PhD, Professor, Liver and Immunology Research center, Daejeon Oriental Hospital of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, South Korea. ckson@dju.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
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World J Gastroenterol. Nov 14, 2014; 20(42): 15703-15714 Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15703
Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model
Hyeong-Geug Kim, Jung-Min Kim, Jong-Min Han, Jin-Seok Lee, Min-Kyung Choi, Dong-Soo Lee, Yeon-Hwa Park, Chang-Gue Son
Hyeong-Geug Kim, Jong-Min Han, Jin-Seok Lee, Min-Kyung Choi, Yeon-Hwa Park, Chang-Gue Son, Liver and immunology research center, Daejeon Oriental Hospital of Oriental Medical Collage of Daejeon University, Daejeon 301-724, South Korea
Jung-Min Kim, NAR center Inc., Daejeon Oriental Hospital of Oriental Medical Collage of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, South Korea
Dong-Soo Lee, Department of Internal Medicine, Daejeon St. Mary’s Hospital, The Catholic University of Korea, Daejeon 301-724, South Korea
Author contributions: Kim HG and Kim JM contributed equally to this work in the study design, statistical analysis of the data and interpretation of the results; Lee DS provided critical reagents and analytical tools; Choi MK performed fingerprinting analysis; Lee JS and supported mainly animal treatment and cell based experiment; Park YH took a part in the statistical analysis of the data; Han JM drafted the manuscript; Kim HG and Son CG described the manuscript critically and provided vital guidance to the study; all authors approved the submission version of the manuscript.
Supported by Oriental Medicine Research and Development Project, Ministry of Health and Welfare, South Korea No. HI12C-1920-01001
Correspondence to: Chang-Gue Son, MD, PhD, Professor, Liver and Immunology Research center, Daejeon Oriental Hospital of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, South Korea. ckson@dju.kr
Telephone: +82-42-2296723 Fax: +82-42-2576398
Received: April 2, 2014 Revised: May 14, 2014 Accepted: June 21, 2014 Published online: November 14, 2014 Processing time: 228 Days and 21.4 Hours
Core Tip
Core tip: We observed that the protective effect of Chunggan extract (CGX) on alcohol induced rat model of hepatic injury. In this study, 4 wk of alcohol consumptions markedly induced hepatic injury. Treatment with CGX significantly reverses and ameliorates pro-fibrogenic cytokines including transforming growth factor-β, platelet-derived growth factor-BB, and connective tissue growth factor. We also revealed the significant effects of alcohol metabolism related molecules by CGX treatment. The pharmacological actions were supported by in vitro assay that acetaldehyde stimulated HSC-T6 cell activation was normalized by CGX. Collectively our results suggest that CGX will be applicable to treat patients with alcoholic liver injury through amelioration of fibrotic changes and alcohol metabolisms.
