Recent studies of 5-fluorouracil resistance in pancreatic cancer

doi:10.3748/wjg.v20.i42.15682

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Nov 14, 2014 (publication date) through Apr 28, 2024

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Nov 14, 2014; 20(42): 15682-15690
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15682

Recent studies of 5-fluorouracil resistance in pancreatic cancer

Wei-Bin Wang, Yu Yang, Yu-Pei Zhao, Tai-Ping Zhang, Quan Liao, Hong Shu

Wei-Bin Wang, Yu Yang, Yu-Pei Zhao, Tai-Ping Zhang, Quan Liao, Hong Shu, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China

Author contributions: Wang WB and Yang Y performed and wrote the paper; Zhao YP designed the study and provided financial support; and Zhang TP, Liao Q and Shu H were involved in reviewing and editing the manuscript.

Supported by The Research Special Fund for the Public Welfare Industry of Health (The Translational Research of Early Diagnosis and Comprehensive Treatment in Pancreatic Cancer, 201202007)

Correspondence to: Yu-Pei Zhao, MD, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuai Fu Yuan, Dongcheng District, Beijing 100005, China. zhao8028@263.net

Telephone: +86-10-69152600 Fax: +86-10-65295818

Received: February 19, 2014
Revised: May 4, 2014
Accepted: July 24, 2014
Published online: November 14, 2014

Core Tip

Core tip: 5-fluorouracil (5-FU) is one of the most important drugs for human pancreatic cancer. Although recent studies have questioned the effectiveness of 5-FU against pancreatic cancer, it remains a good choice for pancreatic cancer. Our paper discusses recent studies that provide novel insights into 5-FU chemotherapy in pancreatic cancer.