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World J Gastroenterol. Nov 14, 2014; 20(42): 15650-15656
Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15650
Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity
Mehrbod Estaki, Daniella DeCoffe, Deanna L Gibson
Mehrbod Estaki, Daniella DeCoffe, Deanna L Gibson, Department of Biology, University of British Columbia Okanagan, Kelowna V1V 1V7, British Columbia, Canada
Author contributions: Estaki M and DeCoffe D contributed equally to this work; Estaki M and DeCoffe D wrote the paper and critically revised the paper for important intellectual content; Gibson DL critically revised the paper for important intellectual content, obtained funding and supervised.
Supported by Crohn’s and Colitis Foundation of Canada, No. 11883 1486 RR 0001; and Natural Science and Engineering Research Council and the Intestinal Diseases Education Awareness Society, No. 86435 5557 RR0001
Correspondence to: Deanna L Gibson, PhD, Assistant Professor, Department of Biology, University of British Columbia Okanagan, Kelowna V1V 1V7, British Columbia, Canada. deanna.gibson@ubc.ca
Telephone: +1-250-8078790 Fax: +1-250-8078005
Received: March 1, 2014
Revised: April 29, 2014
Accepted: May 26, 2014
Published online: November 14, 2014
Core Tip

Core tip: Intestinal alkaline phosphatase (IAP) is important for intestinal health. IAP’s role in the intestine encompasses both protection from systemic infections and chronic inflammatory diseases such as inflammatory bowel disease. There is a complex interplay occurring between IAP, diet, microbiota and the intestinal epithelium which has accelerated research on IAP as a potential therapeutic against these inflictions. The purpose of this review is to highlight the essential characteristics of IAP in maintaining homeostasis in the intestines while addressing the complex interplay between IAP, diet, microbiota and the intestinal epithelium.