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World J Gastroenterol. Nov 7, 2014; 20(41): 15440-15447
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15440
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15440
MiR-146a rs2910164 polymorphism increases risk of gastric cancer: A meta-analysis
Wen-Qun Xie, Shi-Yun Tan, Xiao-Fan Wang, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Xie WQ and Wang XF contributed equally to the literature review and data analysis; Xie WQ, Tan SY and Wang XF designed the study; Xie WQ wrote the paper.
Supported by The Natural Science Foundation of Hubei Province, No. 2013CFA076
Correspondence to: Shi-Yun Tan, Chief Physician, Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 99 Wuchang Ziyang Road, Wuhan 430060, Hubei Province, China. tanshiyun@medmail.com.cn
Telephone: +86-27-88041911 Fax: +86-27-88041911
Received: March 13, 2014
Revised: May 22, 2014
Accepted: July 11, 2014
Published online: November 7, 2014
Processing time: 242 Days and 9.9 Hours
Revised: May 22, 2014
Accepted: July 11, 2014
Published online: November 7, 2014
Processing time: 242 Days and 9.9 Hours
Core Tip
Core tip: Recent attention has been focused on the role of miR-146a gene variants in the etiology of several cancers. An increasing number of studies have suggested that the single nucleotide polymorphism rs2910164 in miR-146a is associated with gastric cancer risk. However, previous meta-analyses have failed to find an association. To better understand this association, an up-to-date comprehensive meta-analysis was conducted, which indicates that the miR-146a rs2910164 polymorphism is indeed more likely to be associated with gastric cancer risk.