Al-Maramhy H, Abdelrahman AI, Sawalhi S. Resistin is not an appropriate biochemical marker to predict severity of acute pancreatitis: A case-controlled study. World J Gastroenterol 2014; 20(41): 15351-15357 [PMID: 25386084 DOI: 10.3748/wjg.v20.i41.15351]
Corresponding Author of This Article
Samer Sawalhi, Assistant Professor, Surgical Consultant, Department of Surgery, College of Medicine, Dalhousie University, Suite 7-012, Victoria Building, VG Site1276, South Park Street, Halifax, NS B3H 2Y9, Canada. skyscraper555@yahoo.com
Research Domain of This Article
Surgery
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
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World J Gastroenterol. Nov 7, 2014; 20(41): 15351-15357 Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15351
Resistin is not an appropriate biochemical marker to predict severity of acute pancreatitis: A case-controlled study
Hamdi Al-Maramhy, Abdelrahman I Abdelrahman, Samer Sawalhi
Hamdi Al-Maramhy, Samer Sawalhi, Department of Surgery, College of Medicine, Taibah University, Al-Madina 30001, Saudi Arabia
Abdelrahman I Abdelrahman, Department of Radiology, King Fahd Hospital, Al-Madina 30001, Saudi Arabia
Samer Sawalhi, Department of Surgery, College of Medicine-Dalhousie University, Halifax, NS B3H 2Y9, Canada
Author contributions: Sawalhi S designed research, collected and analyzed data, prepared database, interpreted results, and wrote the manuscript; Al-Maramhy H designed the questionnaire, collected and analyzed data, interpreted results, prepared and coordinated field work; Abdelrahman AI analyzed radiological data.
Supported by Research grant from scientific research deanship -Taibah University, No. 433/780
Correspondence to: Samer Sawalhi, Assistant Professor, Surgical Consultant, Department of Surgery, College of Medicine, Dalhousie University, Suite 7-012, Victoria Building, VG Site1276, South Park Street, Halifax, NS B3H 2Y9, Canada. skyscraper555@yahoo.com
Telephone: +1-902-3295544 Fax: +1-902-4736144
Received: December 28, 2013 Revised: February 16, 2014 Accepted: April 2, 2014 Published online: November 7, 2014 Processing time: 317 Days and 16.5 Hours
Core Tip
Core tip: Several predictive inflammatory markers have been used to predict pancreatitis severity. Peri-pancreatic adipose tissue synthesizes and secretes adipose-specific proteins, termed adipocytokines. One of these proteins, resistin, has immunomodulatory and metabolic activity. This novel adipose-driven protein, produced by pancreatic islets, may represent a useful additional marker for predicting acute pancreatitis (AP) severity. We found that serum resistin levels were significantly higher in patients with acute biliary pancreatitis compared to control subjects; however, resistin failed to serve as a predictive marker of clinical severity. Our study did find, however, that obesity correlated with severity of acute biliary pancreatitis. Based on the increased levels in AP patients upon hospital admission, we suggest that resistin could be used as a new diagnostic marker.
