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World J Gastroenterol. Nov 7, 2014; 20(41): 15327-15334
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15327
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15327
Intestinal ischemia-reperfusion of macaques triggers a strong innate immune response
Hao Wu, Ling Liu, Qing-Hua Tan, Chun-Hui Wang, Cheng-Wei Tang, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yi-Yun Deng, Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Mei-Mei Guo, Yong-Mei Xie, Laboratory Peptides Related to Human Diseases, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Wu H and Deng YY contributed equally to this work; Tang CW designed the research and revised the manuscript; Wu H, Liu L, Tan QH, Wang CH, Guo MM, Xie YM performed the research; Wu H and Deng YY wrote the paper and analyzed the data.
Supported by Key Grant of the Natural Science Fund of China, No. 30330270; Chengdu Bureau of Science and Technology Research Projects, No. 11DXYB352SF; Chengdu Bureau of Science and Technology Research Projects, No. 12PPYB080SF-002
Correspondence to: Cheng-Wei Tang, MD, PhD, Department of Gastroenterology, West China Hospital, Sichuan University, Guoxue Xiang 37, Chengdu 610041, Sichuan Province, China. cwtang@medmail.com.cn
Telephone: +86-28-85423887 Fax: +86-28-85423887
Received: March 12, 2014
Revised: May 8, 2014
Accepted: June 13, 2014
Published online: November 7, 2014
Processing time: 243 Days and 0.7 Hours
Revised: May 8, 2014
Accepted: June 13, 2014
Published online: November 7, 2014
Processing time: 243 Days and 0.7 Hours
Core Tip
Core tip: After intestine ischemia-reperfusion, general inflammatory injury of the intestinal tract, and the ensuing multiple organ dysfunction syndrome, are correlated with a strong innate immune response, which is mediated by the extensive activation of the Toll-like receptor-nuclear factor-κB-cytokine pathway throughout the whole system.