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World J Gastroenterol. Nov 7, 2014; 20(41): 15299-15309
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15299
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15299
Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative colitis patients
Feng-Yan Yu, Hong-Gang Chi, Ying Zou, Xue-Bao Zheng, Traditional Chinese Medicine Institute Guangdong Medical College, Dongguan 524023, Guangdong Province, China
Shao-Gang Huang, Hai-Yan Zhang, Guangdong Provincial Hospital of University City Branch, Guangzhou 511495, Guangdong Province, China
Hua Ye, Traditional Chinese Medicine Institute Guangdong Medical College, Guangdong Key Laboratory of Natural Medicine Research and Development, Zhanjiang 524023, Guangdong Province, China
Ru-Xi Lv, School of Traditional Chinese Medicine of Southern Medical College, Guangzhou 510515, Guangdong Province, China
Author contributions: Yu FY, Huang SG, Zhang HY, Ye H and Lv RX performed the majority of experiments; Chi HG and Zou Y provided vital reagents and analytical tools and were also involved in editing the manuscript; Zheng XB coordinated and provided the collection of all the human material in addition to providing financial support for this work; Yu FY designed the study and wrote the manuscript.
Supported by National Natural Science Foundation of China under Grant No. 30772701
Correspondence to: Feng-Yan Yu, PhD, Traditional Chinese Medicine Institute Guangdong Medical College, Dalingshan Town Songshan Lake Park, No. 1, Metro Avenue, Dongguan 524023, Guangdong Province, China. yujoyce022@163.com
Telephone: +86- 769-22896208 Fax: +86-769-22896207
Received: April 7, 2014
Revised: June 8, 2014
Accepted: June 26, 2014
Published online: November 7, 2014
Revised: June 8, 2014
Accepted: June 26, 2014
Published online: November 7, 2014
Core Tip
Core tip: Ulcerative colitis is a kind of chronic and non-specific inflammatory bowel disease. Researchers believe that several distinguishing factors such as immune systems, genes and environment are likely necessary to result in ulcerative colitis (UC). The study here demonstrated that baicalin might be a potential immune inhibitor. It adjusted immune balance and relieved the inflammatory response caused by UC, probably by inhibiting the ratio of CD4+CD29+ cells and immunosuppressive pathways. Our results provide valuable information for further studies on the pathogenesis of UC and for the development of new drugs, and also provide a new view of studying T helper cell immune disorder-related diseases including UC.