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World J Gastroenterol. Nov 7, 2014; 20(41): 15070-15078
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15070
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15070
Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease
Ciarán P Fisher, Andrzej M Kierzek, Nick J Plant, J Bernadette Moore, Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, Surrey, United Kingdom
Author contributions: All authors contributed to the preparation of the manuscript.
Supported by The Biotechnology and Biological Sciences Research Council, No. BB/I008195/1
Correspondence to: J Bernadette Moore, PhD, Senior Lecturer in Molecular Nutrition, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, Surrey, United Kingdom. j.b.moore@surrey.ac.uk
Telephone: +44-1483-686405 Fax: +44-1483-686401
Received: November 5, 2013
Revised: February 13, 2014
Accepted: March 12, 2014
Published online: November 7, 2014
Processing time: 370 Days and 12.5 Hours
Revised: February 13, 2014
Accepted: March 12, 2014
Published online: November 7, 2014
Processing time: 370 Days and 12.5 Hours
Core Tip
Core tip: Research into non-alcoholic fatty liver disease (NAFLD) is dominated by human clinical studies and the use of animal models. We postulate that the wider use of systems biology approaches, incorporating novel modelling and simulation strategies, will yield greater insights into the mechanisms underlying NAFLD progression. Such insights are essential to the development of non-invasive diagnostic tools and novel therapies.