Meta-Analysis
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World J Gastroenterol. Oct 28, 2014; 20(40): 14965-14972
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14965
Association between Helicobacter pylori infection and migraine: A meta-analysis
Jing Su, Xiao-Ying Zhou, Guo-Xin Zhang
Jing Su, Xiao-Ying Zhou, Guo-Xin Zhang, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Jing Su, Xiao-Ying Zhou, First Clinical Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Su J and Zhou XY collected and analyzed the data, and wrote the first draft of the paper; These authors contribute equally to the paper; Zhang GX contributed to the study design and proofread the manuscript.
Supported by National Natural Science Foundation of China, No. 81270476; the Priority Academic Program Development of Jiangsu Higher Education Institutions, JX10231801
Correspondence to: Guo-Xin Zhang, Professor, Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No. 300 of Guangzhou Road, Nanjing 210029, Jiangsu Province, China. guoxinz@njmu.edu.cn
Telephone: +86-25-83718836 Fax: +86-25-83674636
Received: November 7, 2013
Revised: March 11, 2014
Accepted: June 13, 2014
Published online: October 28, 2014
Processing time: 355 Days and 23.8 Hours
Core Tip

Core tip: Recently, researchers have focused on the relationship between migraine and Helicobacter pylori (H. pylori) infection. Some studies have reported a strong positive correlation, and eradication of the bacterium resulted in a decrease in migraine attacks. Meanwhile, others have indicated totally negative results. In this meta-analysis, we found a trend of more frequent H. pylori infection in patients with migraine; thus, the eradication of this bacterium may reduce the clinical manifestations in migraineurs. Moreover, subgroup analysis found a significantly greater infection rate of H. pylori in patients with migraine in Asia compared with other countries.