Trovato FM, Catalano D, Garozzo A, Martines GF, Pirri C, Trovato GM. ADV36 adipogenic adenovirus in human liver disease. World J Gastroenterol 2014; 20(40): 14706-14716 [PMID: 25356033 DOI: 10.3748/wjg.v20.i40.14706]
Corresponding Author of This Article
Guglielmo M Trovato, MD, Department of Medical and Pediatric Sciences, Internal Medicine, University of Catania, Policlinico, Ed. 4, 4th floor, Via Santa Sofia, 95100 Catania, Italy. guglielmotrovato@unict.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
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World J Gastroenterol. Oct 28, 2014; 20(40): 14706-14716 Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14706
ADV36 adipogenic adenovirus in human liver disease
Francesca M Trovato, Daniela Catalano, Adriana Garozzo, G Fabio Martines, Clara Pirri, Guglielmo M Trovato
Francesca M Trovato, Daniela Catalano, G Fabio Martines, Clara Pirri, Guglielmo M Trovato, Department of Medical and Pediatric Sciences, Internal Medicine, University of Catania, 95100 Catania, Italy
Adriana Garozzo, Department of Biomedical Science, University of Catania, 95100 Catania, Italy
Author contributions: All authors contributed equally to this work, based on preceding studies and articles; Trovato FM designed and drafted the review; Garozzo A revised the virology aspects; Trovato GM finally edited the paper.
Correspondence to: Guglielmo M Trovato, MD, Department of Medical and Pediatric Sciences, Internal Medicine, University of Catania, Policlinico, Ed. 4, 4th floor, Via Santa Sofia, 95100 Catania, Italy. guglielmotrovato@unict.it
Telephone: +39-95-3781533 Fax: +39-95-3781549
Received: October 25, 2013 Revised: April 3, 2014 Accepted: June 26, 2014 Published online: October 28, 2014 Processing time: 369 Days and 16.1 Hours
Core Tip
Core tip: There is evidence that environmental infections, and notably adipogenic adenoviruses ADV36 /ADV37 infections in humans, are associated with obesity, being causative contributing factors of obesity in humans and animals. Lifestyle-nutritional intervention, in patients with different ADV36 seropositive status, achieves different clinical outcomes, i.e., a greater effect, on bright liver, insulin resistance and obesity is observed in comparison with ADV36 seronegative patients. These effects are not dependent on a greater pre-interventional body weight and older age. Adipogenic adenovirus infections in humans are associated with obesity, but also with allied conditions, such as fatty liver, and can have different effects on the liver in humans and animals.
