Wang C, Han J, Xiao L, Jin CE, Li DJ, Yang Z. Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease. World J Gastroenterol 2014; 20(4): 1079-1087 [PMID: 24574782 DOI: 10.3748/wjg.v20.i4.1079]
Corresponding Author of This Article
Chao Wang, PhD, Department of General Surgery, Tongji Hospital, Tongji Medical College, Science and Technology of Huazhong University, No. 1095, Jiefang Avenue, Wuhan 430030, Hubei Province, China. wangchao75@sina.com
Research Domain of This Article
Surgery
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 28, 2014; 20(4): 1079-1087 Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.1079
Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease
Chao Wang, Juan Han, Liang Xiao, Chang-E Jin, Dong-Jian Li, Zhen Yang
Chao Wang, Dong-Jian Li, Zhen Yang, Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Juan Han, Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Liang Xiao, Department of Surgery and Biological Therapy, Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China
Chang-E Jin, Department of Respiratory Medicine, Shenzhen People’s Hospital, Shenzhen 518020, Guangdong Province, China
Author contributions: Wang C, Han J and Xiao L designed the research; Wang C, Han J, Xiao L, Jin CE, Li DJ and Yang Z performed the research; Wang C, Han J, Xiao L and Jin CE analyzed the data; Wang C, Han J and Xiao L wrote the paper.
Supported by Specialized Research Fund for the Doctoral Program of Higher Education of China, No. 20120142120048; and Natural Science Foundation of Hubei Province, China, No. 2012FFB02308
Correspondence to: Chao Wang, PhD, Department of General Surgery, Tongji Hospital, Tongji Medical College, Science and Technology of Huazhong University, No. 1095, Jiefang Avenue, Wuhan 430030, Hubei Province, China. wangchao75@sina.com
Telephone: +86-27-83663008 Fax: +86-27-83663039
Received: August 16, 2013 Revised: October 14, 2013 Accepted: November 18, 2013 Published online: January 28, 2014 Processing time: 163 Days and 7.3 Hours
Core Tip
Core tip: In portal hypertension patients, endogenous hydrogen sulfide (H2S) levels were significantly lower than those in healthy controls. H2S plasma level reductions correlated with portal vein diameter and Child-Pugh score. In a rabbit hepatic schistosomiasis portal hypertension model, liver tissue H2S concentrations and cystathionine γ-lyase expression were significantly reduced and phosphorylated extracellular signal regulated kinase 1/2 expression gradually increased. Increasing H2S levels led to increased apoptosis of portal vein smooth muscle cells, while B-cell lymphoma-2 (Bcl-2) and Bcl-XL expression decreased. We suggest that H2S prevents portal hypertension though apoptosis induction of otherwise excessive proliferating smooth muscle cells.
