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World J Gastroenterol. Oct 21, 2014; 20(39): 14463-14471
Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14463
Published online Oct 21, 2014. doi: 10.3748/wjg.v20.i39.14463
Gene expression profile of peripheral blood in colorectal cancer
Yu-Tien Chang, Yun-Wen Shih, Chen-En Jian, Chiao-Huang Lin, Chien-Ting Chen, Yi-Syuan Wu, Ke-Shin Lin, Chi-Ming Chu, Division of Biomedical Statistics and Informatics, School of Public Health, National Defense Medical Center, Taipei 114, Taiwan
Chi-Shuan Huang, Division of Colorectal Surgery, Cheng Hsin Rehabilitation Medical Center, Taipei 112, Taiwan
Chung-Tay Yao, Department of Surgery, Cathay General Hospital, Taipei 114, Taiwan
Sui-Lung Su, Ching-Huang Lai, Yu-Ching Chou, Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei 114, Taiwan
Harn-Jing Terng, Advpharma, Inc., New Taipei 114, Taiwan
Hsiu-Ling Chou, Department of Nursing, Far Eastern Memorial Hospital and Oriental Institute of Technology, New Taipei 114, Taiwan
Kang-Hua Chen, Chi-Wen Chang, Department of Nursing, School of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Chian-Yu Lu, Air Force Combatant Command, National Defense Ministry, Taipei 114, Taiwan
Thomas Wetter, Institute of Medical Biometry and Informatics, Heidelberg University, Germany and Department of Biomedical Informatics and Medical Education, University of Washington Seattle, United States
Author contributions: Chu CM and Chang CW designed the research; Shih YW, Chang YT, Terng HJ and Wetter T performed the research; Chu CM, Chang CW, Shih YW, Chang YT, Terng HJ, Wetter T, Chou YC, Su SL, Lai CH, Chen KH, Yao CT, Chou HL, Huang CS, Shih YW, Lu CY, Chen KH, Jian CE, Lin CH, Chen CT, Wu YS and Lin KS analyzed the data; Chu CM, Chang YT, Chang CW, Shih YW, Terng HJ and Wetter T wrote the paper.
Supported by Taiwan’s SBIR promoting program from the Department of Industrial Technology of the Ministry of Economic Affairs, Advpharma, Inc., and the National Defense Medical Center (NDMC), Bureau of Military Medicine, Ministry of Defense, Taiwan
Correspondence to: Chi-Ming Chu, PhD, Professor, Division of Biomedical Statistics and Informatics, School of Public Health, National Defense Medical Center, Mingquan East Road 161, Taipei 114, Taiwan. chuchiming@web.de
Telephone: +886-963367484 Fax: +886-2-87923147
Received: December 31, 2013
Revised: April 8, 2014
Accepted: June 12, 2014
Published online: October 21, 2014
Processing time: 292 Days and 19.5 Hours
Revised: April 8, 2014
Accepted: June 12, 2014
Published online: October 21, 2014
Processing time: 292 Days and 19.5 Hours
Core Tip
Core tip: A novel gene expression profile was associated with colorectal cancer and can potentially be applied to blood-based detection assays. The model that selected MDM2, DUSP6, CPEB4, MMD, and EIF2S3 showed the result in logistic regression analysis (H-L P = 0.460, R2 = 0.853, AUC = 0.978, accuracy = 0.949, specificity = 0.818 and sensitivity = 0.971).