Systematic Reviews
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World J Gastroenterol. Oct 14, 2014; 20(38): 14018-14032
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.14018
Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases
Reza Mirnezami, Brendan J Moran, Kate Harvey, Tom Cecil, Kandiah Chandrakumaran, Norman Carr, Faheez Mohamed, Alexander H Mirnezami
Reza Mirnezami, Section of Biosurgery and Surgical Technology, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Building, St Mary’s Hospital, London W2 1NY, United Kingdom
Brendan J Moran, Kate Harvey, Tom Cecil, Kandiah Chandrakumaran, Faheez Mohamed, National Pseudomyxoma Peritonei Centre, Hampshire Hospitals Foundation Trust, Basingstoke RG24 9NA, United Kingdom
Norman Carr, Alexander H Mirnezami, Somers Cancer Research Building, University of Southampton Cancer Sciences Division, Southampton University Hospital NHS Trust, Southampton SO166YD, United Kingdom
Author contributions: Mirnezami R, Moran BJ, Mohamed F and Mirnezami AH contributed to study conception, literature search and manuscript preparation; Harvey K prepared the manuscript; Cecil T, Chandrakumaran K and Carr N prepared and edited the manuscript.
Supported by Cancer Research United Kingdom; Wessex Medical Research
Correspondence to: Dr. Alexander H Mirnezami, Somers Cancer Research Building, University of Southampton Cancer Sciences Division, Southampton University Hospital NHS Trust, Tremona Road, Southampton SO166YD, United Kingdom. ahm@soton.ac.uk
Telephone: +44-2380-795170  Fax: +44-2380-794020
Received: September 29, 2013
Revised: December 16, 2013
Accepted: June 26, 2014
Published online: October 14, 2014
Processing time: 382 Days and 9.2 Hours
Core Tip

Core tip: Colorectal cancer peritoneal metastases (CPM) confer a dismal prognosis and traditional treatment involving systemic chemotherapy, with or without palliative surgery has poor outcomes. Cytoreductive surgery (CRS) combined with intraperitoneal chemotherapy (IPC) is now advocated for selected patients with CPM. The present study provides a comprehensive summary of the available evidence relating to CRS in combination with IPC in the setting of CPM, focusing on techniques, oncological outcomes, and complications.