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World J Gastroenterol. Oct 7, 2014; 20(37): 13546-13555
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13546
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13546
Study of liver cirrhosis over ten consecutive years in Southern China
Xing Wang, Shang-Xiong Lin, Jin Tao, Xiu-Qing Wei, Bin Wu, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Yuan-Ting Liu, Statistics Room, Information Section, Central Hospital of Panyu District, Guangzhou 511400, Guangdong Province, China
Yu-Ming Chen, School of Public Health, Zhongshan Medical School of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Author contributions: Wang X and Lin SX contributed equally to this work; Wang X, Lin SX and Wu B designed the research; Wang X, Lin SX, Tao J, Wei XQ and Wu B performed the research; Wang X, Liu YT and Chen YM analyzed the data; and Wang X and Wu B wrote the paper.
Supported by Grants (in part) from the Major Projects Incubator Program of National Key Basic Research Program of China, No. 2012CB526700; National Natural Science Foundation of China, No. 81370511; Natural Science Foundation of Guangdong Province, No. S2011020002348; and Fundamental Research Funds for the Central Universities, No. 13ykjc01 and No. 82000-3281901
Correspondence to: Bin Wu, MD, PhD, Professor, Chairman, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. binwu001@hotmail.com
Telephone: +86-20-85253095 Fax: +86-20-85253336
Received: April 7, 2014
Revised: May 21, 2014
Accepted: June 26, 2014
Published online: October 7, 2014
Revised: May 21, 2014
Accepted: June 26, 2014
Published online: October 7, 2014
Core Tip
Core tip: Liver cirrhosis (LC) is an important cause of death globally, and prevention and treatment based on etiology is fundamental. Large-sample epidemiology studies of the distribution and changes of etiology in the Southern China population are rare. This study illustrates that the major etiology of LC in Southern China is viral hepatitis, and the proportions of viral hepatitis and hepatitis B virus (HBV) are decreasing; whereas autoimmune, cryptogenic, and mixed etiology cases are increasing. Alcoholic LC patients exhibit a greater risk of suffering from upper gastrointestinal bleeding, and HBV LC patients exhibit greater risk of developing hepatocellular carcinoma.