Vasuri F, Malvi D, Rosini F, Baldin P, Fiorentino M, Paccapelo A, Ercolani G, Pinna AD, Golfieri R, Morselli-Labate AM, Grigioni WF, D’Errico-Grigioni A. Revisiting the role of pathological analysis in transarterial chemoembolization-treated hepatocellular carcinoma after transplantation. World J Gastroenterol 2014; 20(37): 13538-13545 [PMID: 25309084 DOI: 10.3748/wjg.v20.i37.13538]
Corresponding Author of This Article
Antonia D’Errico-Grigioni, MD, “F. Addarii” Institute of Oncology and Transplantation Pathology, S.Orsola-Malpighi Hospital, Bologna University, V.le Ercolani 4/2, 40138 Bologna, Italy. derrico@aosp.bo.it
Research Domain of This Article
Pathology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 7, 2014; 20(37): 13538-13545 Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13538
Revisiting the role of pathological analysis in transarterial chemoembolization-treated hepatocellular carcinoma after transplantation
Francesco Vasuri, Deborah Malvi, Francesca Rosini, Pamela Baldin, Michelangelo Fiorentino, Alexandro Paccapelo, Giorgio Ercolani, Antonio Daniele Pinna, Rita Golfieri, Antonio Maria Morselli-Labate, Walter Franco Grigioni, Antonia D’Errico-Grigioni
Francesco Vasuri, Deborah Malvi, Francesca Rosini, Pamela Baldin, Michelangelo Fiorentino, Walter Franco Grigioni, Antonia D’Errico-Grigioni, “F. Addarii” Institute of Oncology and Transplantation Pathology, S.Orsola-Malpighi Hospital, Bologna University, 40138 Bologna, Italy
Alexandro Paccapelo, Antonio Maria Morselli-Labate, Department of Medical and Surgical Sciences, Bologna University, 40138 Bologna, Italy
Giorgio Ercolani, Antonio Daniele Pinna, Department of Surgery and Transplantation, S.Orsola-Malpighi Hospital, Bologna University, 40138 Bologna, Italy
Rita Golfieri, Radiology Unit, S. Orsola-Malpighi Hospital, Bologna University, 40138 Bologna, Italy
Author contributions: Vasuri F designed and performed the research, revised the histology, collected and analyzed data, wrote the manuscript; Malvi D performed the research, revised the histology, wrote the manuscript; Rosini F, Baldin P and Fiorentino M revised the histology and collected pathological data; Paccapelo A and Morselli-Labate AM performed the statistical analysis and calculate the histological score; Ercolani G and Pinna AD collected clinical data and critically reviewed the manuscript; Golfieri R and Grigioni WF analyzed data and critically reviewed the manuscript; D’Errico-Grigioni A designed the research and critically reviewed the manuscript.
Correspondence to: Antonia D’Errico-Grigioni, MD, “F. Addarii” Institute of Oncology and Transplantation Pathology, S.Orsola-Malpighi Hospital, Bologna University, V.le Ercolani 4/2, 40138 Bologna, Italy. derrico@aosp.bo.it
Telephone: +39-51-6364546 Fax: +39-51-6364403
Received: February 16, 2014 Revised: April 18, 2014 Accepted: May 25, 2014 Published online: October 7, 2014
Core Tip
Core tip: Transarterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) is used for down-staging before orthotopic liver transplantation (OLT), and as “bridging therapy” to reduce the drop-out rates in the waiting list. A discrepancy exists between the pre-transplant (radiological) and post-transplant (pathological) staging. Few study analyzing the histology of TACE-treated HCC exist. Here we analyzed 11 histological variables in 275 nodules from 101 consecutive OLT recipients and we computed a histological score to stratify recipients into 3 risk groups, with 3.3%, 18.5% and 53.8% respectively of tumor recurrence rates. The histological score allows a better stratification of those recipients beyond the Milan criteria after OLT.
