Complex interactions between microRNAs and hepatitis B/C viruses

doi:10.3748/wjg.v20.i37.13477

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Oct 7, 2014 (publication date) through Apr 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2014; 20(37): 13477-13492
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13477

Complex interactions between microRNAs and hepatitis B/C viruses

Hong-Xia Fan, Hua Tang

Hong-Xia Fan, Hua Tang, Tianjin Life Science Research Center and Department of Microbiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China

Author contributions: Both authors contributed to the search and analysis of literature and to the writing of the paper.

Supported by National Natural Science Foundation of China, No. 91029714, No. 31071191, No. 31270818 and No. 31101000; and Natural Science Foundation of Tianjin, No. 09JCZDJC175 00 and No. 12JCZDJC25100

Correspondence to: Hua Tang, MD, PhD, Professor, Tianjin Life Science Research Center and Department of Microbiology, School of Basic Medical Sciences, Tianjin Medical University, No. 22, Qi-Xiang-Tai Road, Tianjin 300070, China. htang2002@yahoo.com

Telephone: +86-22-83336836 Fax: +86-22-83336836

Received: January 15, 2014
Revised: March 28, 2014
Accepted: June 2, 2014
Published online: October 7, 2014

Core Tip

Core tip: Chronic hepatitis B virus or hepatitis C virus infection changed miRNA expression profiles at the tissue or serum level, and the altered miRNAs play pivotal roles in gene expression and replication of the viruses and the development of virus-related diseases. These findings suggest that miRNAs have the potential as novel diagnostic and prognostic biomarkers and therapeutic targets in virus-related diseases.