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World J Gastroenterol. Oct 7, 2014; 20(37): 13477-13492
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13477
Published online Oct 7, 2014. doi: 10.3748/wjg.v20.i37.13477
Complex interactions between microRNAs and hepatitis B/C viruses
Hong-Xia Fan, Hua Tang, Tianjin Life Science Research Center and Department of Microbiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
Author contributions: Both authors contributed to the search and analysis of literature and to the writing of the paper.
Supported by National Natural Science Foundation of China, No. 91029714, No. 31071191, No. 31270818 and No. 31101000; and Natural Science Foundation of Tianjin, No. 09JCZDJC175 00 and No. 12JCZDJC25100
Correspondence to: Hua Tang, MD, PhD, Professor, Tianjin Life Science Research Center and Department of Microbiology, School of Basic Medical Sciences, Tianjin Medical University, No. 22, Qi-Xiang-Tai Road, Tianjin 300070, China. htang2002@yahoo.com
Telephone: +86-22-83336836 Fax: +86-22-83336836
Received: January 15, 2014
Revised: March 28, 2014
Accepted: June 2, 2014
Published online: October 7, 2014
Processing time: 265 Days and 8.8 Hours
Revised: March 28, 2014
Accepted: June 2, 2014
Published online: October 7, 2014
Processing time: 265 Days and 8.8 Hours
Core Tip
Core tip: Chronic hepatitis B virus or hepatitis C virus infection changed miRNA expression profiles at the tissue or serum level, and the altered miRNAs play pivotal roles in gene expression and replication of the viruses and the development of virus-related diseases. These findings suggest that miRNAs have the potential as novel diagnostic and prognostic biomarkers and therapeutic targets in virus-related diseases.