Zhang Y, Wang ZN, He L, Gao G, Zhai Q, Yin ZT, Zeng XD. Botulinum toxin type-A injection to treat patients with intractable anismus unresponsive to simple biofeedback training. World J Gastroenterol 2014; 20(35): 12602-12607 [PMID: 25253964 DOI: 10.3748/wjg.v20.i35.12602]
Corresponding Author of This Article
Xian-Dong Zeng, MD, PhD, Department of Constipation and Pelvic Floor Disease, Constipation Treatment Center, Shenyang Coloproctology Hospital, No. 9 Najingbei Street, Heping district, Shenyang 110002, Liaoning Province, China. zengxiandong1969@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 21, 2014; 20(35): 12602-12607 Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12602
Botulinum toxin type-A injection to treat patients with intractable anismus unresponsive to simple biofeedback training
Yong Zhang, Zhen-Ning Wang, Lei He, Ge Gao, Qing Zhai, Zhi-Tao Yin, Xian-Dong Zeng
Yong Zhang, Lei He, Ge Gao, Qing Zhai, Zhi-Tao Yin, Xian-Dong Zeng, Department of Constipation and Pelvic Floor Disease, Constipation Treatment Center, Shenyang Coloproctology Hospital, Shenyang 110002, Liaoning Province, China
Yong Zhang, Zhen-Ning Wang, Department of Oncology, No. 1 Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Zhang Y performed the majority of the clinical therapy and data analysis, and wrote the paper; Wang ZN advised the design and performance of the study; He L and Gao G performed the follow-up and the initial data analysis; Zhai Q provided the three-dimensional endoluminal ultrasonography support; Yin ZT performed ethical supervision and provided the effect evaluation system; Zeng XD designed the study, provided the founding, and was responsible for the paper’s reliability.
Supported by Foundation of Science and Technology Plan Projects of Shenyang, No. P112238
Correspondence to: Xian-Dong Zeng, MD, PhD, Department of Constipation and Pelvic Floor Disease, Constipation Treatment Center, Shenyang Coloproctology Hospital, No. 9 Najingbei Street, Heping district, Shenyang 110002, Liaoning Province, China. zengxiandong1969@163.com
Telephone: +86-24-22511990 Fax: +86-24-22533338
Received: March 8, 2014 Revised: April 30, 2014 Accepted: June 12, 2014 Published online: September 21, 2014 Processing time: 195 Days and 10.5 Hours
Core Tip
Core tip: Pelvic floor biofeedback was accepted to be an effective therapy for anismus. However, unfortunately the treatment proved to be ineffective in some cases. In our study, we performed biofeedback training combined with botulinum toxin type A injection to the puborectalis and external sphincter. Diagnosis was made by anorectal manometry, balloon expulsion test, surface electromyography of the pelvic floor muscle, and defecography. Follow-up was conducted before the paper was written. Improvement was evaluated using the chronic constipation scoring system. Botulinum toxin type A injection combined with pelvic floor biofeedback training achieved success in 24 (24/31) patients, with 23 maintaining persistent satisfaction during a mean period of 8.4 mo.
