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World J Gastroenterol. Sep 14, 2014; 20(34): 12355-12358
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12355
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12355
Surgical resection of advanced gastric cancer following trastuzumab/oxaliplatin/capecitabine combination therapy
Cai-Xia Dong, Xian-Yun Ye, Xiao-Fen Li, Ying Yuan, Department of Medical Oncology, 2nd Hospital of Zhejiang University College of Medicine, Hangzhou 310009, Zhejiang Province, China
Jian-Fei Fu, Department of Oncology, Jinhua Central Hospital, Jinhua 321000, Zhejiang Province, China
Xian Zhong, Department of Medical Oncology, Hangzhou Binjiang Hospital, Hangzhou 310052, Zhejiang Province, China
Author contributions: Dong CX and Yuan Y designed the research; Dong CX, Fu JF and Ye XY performed the research; Dong CX, Li XF, Zhong X and Yuan Y analyzed the data; Dong CX and Yuan Y wrote the paper.
Correspondence to: Ying Yuan, MD, Department of Medical Oncology, 2nd Hospital of Zhejiang University College of Medicine, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. yuanying1999@zju.edu.cn
Telephone: +86-571-87784795 Fax: +86-571-87767088
Received: January 10, 2014
Revised: March 20, 2014
Accepted: May 12, 2014
Published online: September 14, 2014
Processing time: 222 Days and 3.5 Hours
Revised: March 20, 2014
Accepted: May 12, 2014
Published online: September 14, 2014
Processing time: 222 Days and 3.5 Hours
Core Tip
Core tip: Surgical resection of advanced gastric cancer is accompanied by a high frequency of recurrences and metastases. To curb cancerous cell growth, cytostatic medications are commonly used; however, tumor cell-specific drugs are being researched increasingly. Human epidermal growth factor receptor 2 (HER2) has been recognized as a target for breast cancer medications, and the application of the monoclonal antibody trastuzumab led to remissions of HER2-positive breast cancers, which comprise about 30% of all cases. HER2 overexpression was also detected in gastric cancers; therefore, trastuzumab as an adjuvant or neoadjuvant therapy has been used as a new approach to treat these tumors.