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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2014; 20(34): 12018-12025
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12018
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12018
Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients
Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidis, Department of Nephrology, Medical School, University of Thessaly, 41110 Larissa, Greece
Author contributions: Eleftheriadis T, Pissas G, Antoniadi G, Liakopoulos V and Stefanidis I were responsible for review the literature and initial preparation of the manuscript; Eleftheriadis T prepared the final version of the manuscript.
Correspondence to: Theodoros Eleftheriadis, MD, PhD, Department of Nephrology, Medical School, University of Thessaly, Neo Ktirio, Mezourlo Hill, 41110 Larissa, Greece. teleftheriadis@yahoo.com
Telephone: +30-24-13501668 Fax: +30-24-13500242
Received: October 27, 2013
Revised: January 29, 2014
Accepted: April 8, 2014
Published online: September 14, 2014
Processing time: 326 Days and 3.7 Hours
Revised: January 29, 2014
Accepted: April 8, 2014
Published online: September 14, 2014
Processing time: 326 Days and 3.7 Hours
Core Tip
Core tip: The prevalence of hepatitis B virus (HBV) infection among the hemodialysis (HD) patients is still high. Although vaccination against HBV has became a necessity in this population, the seroprotection achieved in HD patients remains relatively low. In this review patient, HD procedure and vaccine-associated factors that affect the efficacy of HBV vaccination are analyzed. The alternative routes of HBV vaccine administration as well as new and more immunogenic vaccine formulations are discussed with a detailed view of the protocols that increase HBV vaccination efficacy.