Characterization of monocarboxylate transporter activity in hepatocellular carcinoma

doi:10.3748/wjg.v20.i33.11780

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2014; 20(33): 11780-11787
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11780

Characterization of monocarboxylate transporter activity in hepatocellular carcinoma

Venâncio A Alves, Céline Pinheiro, Filipa Morais-Santos, Aloisio Felipe-Silva, Adhemar Longatto-Filho, Fátima Baltazar

Venâncio A Alves, Aloisio Felipe-Silva, Adhemar Longatto-Filho, Laboratory of Medical Investigation (LIM) 14, Department of Pathology, University of São Paulo School of Medicine, São Paulo, SP 1246-903, Brazil

Céline Pinheiro, Filipa Morais-Santos, Adhemar Longatto-Filho, Fátima Baltazar, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4704-553 Braga, Portugal

Céline Pinheiro, Filipa Morais-Santos, Adhemar Longatto-Filho, Fátima Baltazar, ICVS/3B’s-PT Government Associate Laboratory, 4710-057 Braga/ Guimarães, Portugal

Céline Pinheiro, Barretos School of Health Sciences, Dr. Paulo Prata-FACISB, Barretos, São Paulo, SP 13083-970, Brazil

Céline Pinheiro, Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Sao Paulo, 14780-000, Brazil

Adhemar Longatto-Filho, Molecular Oncology Research Center, Barretos Cancer Hospital, Pio XII Foundation, Barretos 14780-000, Brazil

Author contributions: All the authors contributed to this manuscript.

Correspondence to: Venâncio A Alves, MD, PhD, Professor, Laboratory of Medical Investigation (LIM) 14, Department of Pathology, University of São Paulo School of Medicine, Brazil, Dr. Arnaldo Ave. 455 Room 1153, São Paulo, SP 1246-903, Brasil. venancio@uol.com.br

Telephone: +55-11-30617413 Fax: +55-11-30617413

Received: January 12, 2014
Revised: March 7, 2014
Accepted: June 14, 2014
Published online: September 7, 2014

Core Tip

Core tip: This paper describes, for the first time, the role of monocarboxylate transporters in hepatic carcinoma. The characterization of monocarboxylate transporter activity in acidic metabolism of primary and metastatic hepatocellular carcinoma microenvironment was studied in necropsy material and allowed us to precisely evaluate the impact of the more acidic microenvironment that is potentially maintained by monocarboxylate transporter 4 and glucose transporter-1 during hepatocellular carcinoma progression.