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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2014; 20(33): 11736-11742
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11736
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11736
Impact of Clostridium difficile infection on inflammatory bowel disease outcome: A review
Anca Trifan, Camelia Cojocariu, “Gr. T. Popa” University of Medicine and Pharmacy, “St. Spiridon” Emergency Hospital, Institute of Gastroenterology and Hepatology, 7000111 Iasi, Romania
Carol Stanciu, “St. Spiridon” Emergency Hospital, Institute of Gastroenterology and Hepatology, 7000111 Iasi, Romania
Oana Stoica, Irina Girleanu, “Gr. T. Popa” University of Medicine and Pharmacy, 7000111 Iasi, Romania
Author contributions: Trifan A contributed to the conception and design of the review, analyzed the data, coordinated the manuscript drafting and critical revision of the manuscript; Stanciu C contributed to the conception and the design of the review, analyzed the data, coordinated the manuscript drafting and revised it critically; Stoica O and Girleanu I performed acquisition of data; Cojocariu C participated in the design of the review, collected the data; all authors read and approved the final version of the manuscript.
Correspondence to: Carol Stanciu, MD, PhD, FRCP, Professor, “St. Spiridon” Emergency Hospital, Institute of Gastroenterology and Hepatology, Independentei 1, 7000111 Iasi, Romania. stanciucarol@yahoo.com
Telephone: +40-732-402860 Fax: +40-232-246611
Received: February 11, 2014
Revised: April 23, 2014
Accepted: June 12, 2014
Published online: September 7, 2014
Revised: April 23, 2014
Accepted: June 12, 2014
Published online: September 7, 2014
Core Tip
Core tip: This review summarizes the impact of Clostridium difficile infection (CDI) on inflammatory bowel disease (IBD) outcome. Most of the studies showed that IBD patients with CDI have more of the whole range of short- and long-term worst outcomes than those without CDI. Patients with ulcerative colitis have more severe outcomes than those with Crohn’s disease. A prompt diagnosis and adequate treatment of CDI are of paramount importance to improve IBD patients’ outcome.