Review
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World J Gastroenterol. Sep 7, 2014; 20(33): 11713-11726
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11713
Bovine immunoglobulin protein isolates for the nutritional management of enteropathy
Bryon W Petschow, Anthony T Blikslager, Eric M Weaver, Joy M Campbell, Javier Polo, Audrey L Shaw, Bruce P Burnett, Gerald L Klein, J Marc Rhoads
Bryon W Petschow, Eric M Weaver, Audrey L Shaw, Bruce P Burnett, Gerald L Klein, Entera Health, Inc., NC 27518, United States
Anthony T Blikslager, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, United States
Joy M Campbell, APC, Inc., Ankeny, IA 50021, United States
Javier Polo, APC Europe, S.A., Barcelona, E-08403, Spain
J Marc Rhoads, University of Texas Health Sciences Center, Houston, TX 77030, United States
Author contributions: Petschow BW, Weaver EM and Rhoads JM wrote the paper and made critical contributions to its intellectual content; Blikslager AT, Campbell JM, Polo J, Shaw AL and Burnett BP reviewed and edited the paper; Klein GL and Rhoads JM had primary responsibility for the final content.
Correspondence to: Bryon W Petschow, PhD, Entera Health, Inc., 2000 Regency Parkway, Suite 255 Cary, NC 27518, United States. bryon.petschow@enterahealth.com
Telephone: +1-919-6160014 Fax: +1-919-3191437
Received: April 16, 2014
Revised: June 9, 2014
Accepted: July 11, 2014
Published online: September 7, 2014
Core Tip

Core tip: This review article summarizes previous preclinical and clinical studies with serum- or plasma-derived protein preparations with an emphasis on potential benefits for intestinal health and recovery from intestinal disorders. Specifically, how serum-derived bovine immunoglobulin/protein preparations may be useful in restoring intestinal homeostasis (e.g., gut barrier function, immune regulation) following episodes of enteropathy associated with various human disease conditions, such as human immunodeficiency virus infection, inflammatory bowel disease, or irritable bowel syndrome.