Miao RL, Wu AW. Towards personalized perioperative treatment for advanced gastric cancer. World J Gastroenterol 2014; 20(33): 11586-11594 [PMID: 25206266 DOI: 10.3748/wjg.v20.i33.11586]
Corresponding Author of This Article
Ai-Wen Wu, MD, PhD, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Gastrointestinal Surgery, Peking University Cancer Hospital, Beijing Cancer Hospital and Institute, Fucheng Road No. 52, Haidian District, Beijing 100142, China. wuaw@sina.com
Research Domain of This Article
Oncology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
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World J Gastroenterol. Sep 7, 2014; 20(33): 11586-11594 Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11586
Towards personalized perioperative treatment for advanced gastric cancer
Ru-Lin Miao, Ai-Wen Wu
Ru-Lin Miao, Ai-Wen Wu, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Gastrointestinal Surgery, Peking University Cancer Hospital, Beijing Cancer Hospital and Institute, Beijing 100142, China
Author contributions: Wu AW conceptualized the manuscript; Miao RL and Wu AW wrote and revised the manuscript.
Supported by Grants from the Natural Sciences Foundation of China, No. 81071983; and Beijing High-level Talents Project (2013)
Correspondence to: Ai-Wen Wu, MD, PhD, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Gastrointestinal Surgery, Peking University Cancer Hospital, Beijing Cancer Hospital and Institute, Fucheng Road No. 52, Haidian District, Beijing 100142, China. wuaw@sina.com
Telephone: +86-10-88196598 Fax: +86-10-88122437
Received: October 22, 2013 Revised: March 10, 2014 Accepted: May 28, 2014 Published online: September 7, 2014 Processing time: 320 Days and 2.1 Hours
Core Tip
Core tip: Multimodal perioperative treatment of advanced gastric cancer is playing an increasingly important role in patient treatment. Different strategies, including preoperative and postoperative chemotherapy and radiochemotherapy, are implemented in clinical practice and a new concept of perioperative-targeted therapy is emerging. Although many randomized clinical trials have been performed to determine the effectiveness of these therapies over surgery alone, little evidence exists regarding the comparison of the different therapies. Personalized treatment should be based on the results of randomized clinical trials as well as subgroup analyses, tailored by histology, demography, and predictors, including tumor markers and genomic profiling.
