Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications

doi:10.3748/wjg.v20.i33.11574

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2014; 20(33): 11574-11585
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11574

Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications

Danilo do Rosário Pinheiro, Wallax Augusto Silva Ferreira, Mariceli Baia Leão Barros, Mariana Diniz Araújo, Symara Rodrigues-Antunes, Bárbara do Nascimento Borges

Danilo do Rosário Pinheiro, Master Program of Animal Health and Production, Federal Rural University of Amazonia, Belém PA 66077-530, Brazil

Danilo do Rosário Pinheiro, Wallax Augusto Silva Ferreira, Mariceli Baia Leão Barros, Mariana Diniz Araújo, Symara Rodrigues-Antunes, Bárbara do Nascimento Borges, Molecular Biology Laboratory, Biological Science Institute, Federal University of Pará, Belém PA 66075-110, Brazil

Bárbara do Nascimento Borges, Center of Agropecuary Technology, Socio-environmental and Hydric Resources Institute, Federal Rural University of Amazonia, Belém PA 66077-530, Brazil

Author contributions: Pinheiro DR, Ferreira WAS, Barros MBL, Araújo MD, Rodrigues-Antunes S and Borges BN wrote the paper.

Correspondence to: Bárbara do Nascimento Borges, PhD, Center of Agropecuary Technology, Socio-environmental and Hydric Resources Institute, Federal Rural University of Amazonia, Avenida Presidente Tancredo Neves 2501, Belém PA 66077-530, Brazil. barbara.borges@ufra.edu.br

Telephone: +55-91-32017585 Fax: +55-91-32017585

Received: October 22, 2013
Revised: March 14, 2014
Accepted: April 30, 2014
Published online: September 7, 2014
Processing time: 319 Days and 17.7 Hours

Core Tip

Core tip: Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, a combination of several approaches (genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. Considering this point of view, this review aims to discuss the most studied biomarkers, discussing the pros and cons of each type of marker and their use in the clinical practice.