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World J Gastroenterol. Sep 7, 2014; 20(33): 11560-11566
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11560
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11560
Cellular physiological approach for treatment of gastric cancer
Atsushi Shiozaki, Daisuke Ichikawa, Eigo Otsuji, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Yoshinori Marunaka, Departments of Molecular Cell Physiology and Bio-Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Yoshinori Marunaka, Japan Institute for Food Education and Health, St. Agnes’ University, Kyoto 602-8013, Japan
Author contributions: Shiozaki A designed the study and wrote the manuscript; Ichikawa D and Otsuji E were involved in editing the manuscript; Marunaka Y designed the study and was involved in editing the manuscript.
Correspondence to: Atsushi Shiozaki, Assistant Professor, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan. shiozaki@koto.kpu-m.ac.jp
Telephone: +81-75-2515527 Fax: +81-75-2515522
Received: October 28, 2013
Revised: January 10, 2014
Accepted: April 1, 2014
Published online: September 7, 2014
Processing time: 314 Days and 5 Hours
Revised: January 10, 2014
Accepted: April 1, 2014
Published online: September 7, 2014
Processing time: 314 Days and 5 Hours
Core Tip
Core tip: This article aims to systematically review the current knowledge on expression and functioning of ion transporters in gastric cancer (GC). Various types of ion channels, water channels and regulators of intracellular pH have been found to express in GC, and to control tumorigenesis. Our studies indicate the intracellular Cl- concentration could control cell cycle progression in GC cells. Further, we demonstrate the cytocidal effects of hypotonic shock, and indicate that regulation of ion transport enhances these effects. A deeper understanding of molecular mechanisms may lead to the discovery of these cellular physiological approaches as a novel therapeutic strategy for GC.