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World J Gastroenterol. Sep 7, 2014; 20(33): 11505-11524
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11505
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11505
Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease
Rok Orel, Tina Kamhi Trop, Department of Gastroenterology, Hepatology and Nutrition, Children’s Hospital, University Medical Centre, 1000 Ljubljana, Slovenia
Author contributions: Orel R performed research, wrote the paper and made final approval of the version to be published; Kamhi Trop T performed research and wrote the paper.
Correspondence to: Rok Orel, MD, PhD, Professor, Department of Gastroenterology, Hepatology and Nutrition, Children’s Hospital, University Medical Centre, Bohoriceva 20, 1000 Ljubljana, Slovenia. rok.orel@kclj.si
Telephone: +386-1-5229276 Fax: +386-1-5229620
Received: September 21, 2013
Revised: January 6, 2014
Accepted: June 12, 2014
Published online: September 7, 2014
Revised: January 6, 2014
Accepted: June 12, 2014
Published online: September 7, 2014
Core Tip
Core tip: Intestinal microbiota seems to play an important role in the pathogenesis of inflammatory bowel disease. There is very strong evidence supporting the use of certain probiotics and prebiotics in the therapy of ulcerative colitis and pouchitis, whereas their beneficial role in Crohn’s disease has not yet been proven. This article describes the role of gut microbiota in the pathogenesis of inflammatory bowel disease and delineates the possible mechanisms of certain probiotics and prebiotics in disease treatment and maintenance of remission.