Lobatón T, Azuara D, Rodríguez-Moranta F, Loayza C, Sanjuan X, de Oca J, Fernández-Robles A, Guardiola J, Capellá G. Relationship between methylation and colonic inflammation in inflammatory bowel disease. World J Gastroenterol 2014; 20(30): 10591-10598 [PMID: 25132780 DOI: 10.3748/wjg.v20.i30.10591]
Corresponding Author of This Article
Triana Lobatón, MD, Department of Gastroenterology, University Hospital of Bellvitge, IDIBELL, Hospitalet del Llobregat, Gran Via 144, 08907 Barcelona, Spain. tlobaton@bellvitgehospital.cat
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 14, 2014; 20(30): 10591-10598 Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10591
Relationship between methylation and colonic inflammation in inflammatory bowel disease
Triana Lobatón, Daniel Azuara, Francisco Rodríguez-Moranta, Carolina Loayza, Xavier Sanjuan, Javier de Oca, Ana Fernández-Robles, Jordi Guardiola, Gabriel Capellá
Triana Lobatón, Francisco Rodríguez-Moranta, Jordi Guardiola, Department of Gastroenterology, University Hospital of Bellvitge, IDIBELL, Hospitalet de Llobregat, 08907 Barcelona, Spain
Daniel Azuara, Ana Fernández-Robles, Gabriel Capellá, Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, Hospitalet de Llobregat, 08907 Barcelona, Spain
Carolina Loayza, Xavier Sanjuan, Department of Pathology, University Hospital of Bellvitge, IDIBELL, Hospitalet de Llobregat, 08907 Barcelona, Spain
Javier de Oca, Department of Surgery, Colorectal Unit, University Hospital of Bellvitge, IDIBELL, Hospitalet de Llobregat, 08907 Barcelona, Spain
Author contributions: Lobatón T was the guarantor of the article; Ortega TL contributed to the study design, data collection, methylation analysis, statistical analysis, interpretation and manuscript writing; Azuara D contributed to the study design, methylation analysis, statistical analysis, interpretation and manuscript writing; Rodríguez-Moranta F contributed to the study design, colonoscopies, statistical analysis, interpretation and manuscript writing; Loayza C and Sanjuan X contributed to the histological analysis; de Oca J contributed to the study design, statistical analysis, interpretation and manuscript writing; Fernández-Robles A contributed to the methylation analysis; Guardiola J contributed to the study design, colonoscopies and sample collection; Capellá G contributed to the study design and manuscript writing.
Supported by Grants from Fondo de Investigación Sanitaria, FIS 12/01420; Ministerio de Ciencia e Innovación, SAF 09-07319, 12-33636; Fundació Gastroenterologia Dr. Francisco Vilardell, F05-01; Ministerio de Educación y Ciencia Spanish Networks RTICC, RD06/0020/0021, 1050 and 1051; RD12/0036/0031 and Fundación Científica de la Asociación Española contra el Cáncer Triana Lobaton supported by a grant from the Institut d’Investigació Biomédica de Bellvitge (IDIBELL)
Correspondence to: Triana Lobatón, MD, Department of Gastroenterology, University Hospital of Bellvitge, IDIBELL, Hospitalet del Llobregat, Gran Via 144, 08907 Barcelona, Spain. tlobaton@bellvitgehospital.cat
Telephone: +34-9-32607623 Fax: +34-9-32607603
Received: January 7, 2014 Revised: March 2, 2014 Accepted: April 21, 2014 Published online: August 14, 2014 Processing time: 221 Days and 19.9 Hours
Core Tip
Core tip: In this paper, we analyze the relationship between the methylation status of selected genes (TGFB2, SLIT2) and the inflammation status (according to endoscopic and histological activity) in ulcerative colitis and Crohn’s colitis patients with increased risks for colorectal cancer. We observed that methylation correlated better with histological activity than with endoscopic activity. SLIT2 and TGFB2 were more frequently methylated in the distal colon. In the multivariate analysis after adjusting for disease extension, disease duration and inflammatory status, only inflammatory status was an independent predictor of methylation. We also observed that the maintenance of histological healing with time might be protective for methylation.
