Retrospective Study
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World J Gastroenterol. Aug 14, 2014; 20(30): 10537-10544
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10537
Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer
Nan Jiang, Jing-Yu Deng, Xue-Wei Ding, Bin Ke, Ning Liu, Ru-Peng Zhang, Han Liang
Nan Jiang, Jing-Yu Deng, Xue-Wei Ding, Bin Ke, Ning Liu, Ru-Peng Zhang, Han Liang, Key Laboratory of Cancer Prevention and Therapy, Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China
Nan Jiang, Jing-Yu Deng, Xue-Wei Ding, Bin Ke, Ning Liu, Ru-Peng Zhang, Han Liang, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China
Author contributions: Jiang N, Liang H and Deng JY performed the majority of the study; Deng JY, Ding XW, Ke B, Liu N and Zhang RP designed the study and analyzed the data; Jiang N and Liang H wrote the manuscript; Deng JY and Ding XW revised the manuscript.
Supported by National Basic Research Program of China (973 Program), No. 2010CB529301; and the Key Program for Anti-cancer Research of Tianjin Municipal Science and Technology Commission, No. 12ZCDZSY16400
Correspondence to: Han Liang, MD, Key Laboratory of Cancer Prevention and Therapy, Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Ti-Yuan-Bei, Huan-Hu-Xi Road, He Xi District, Tianjin 300060, China. tjlianghan@gmail.com
Telephone: +86-22-23340123 Fax: +86-22-23340123
Received: December 16, 2013
Revised: March 12, 2014
Accepted: April 30, 2014
Published online: August 14, 2014
Processing time: 245 Days and 0.6 Hours
Core Tip

Core tip: Prognostic nutritional index (PNI) has been shown to be associated with poor outcomes in various types of malignancy. The low PNI was an independent risk factor for the incidence of postoperative complications and an independent predictor of poor overall survival (OS) in gastric cancer patients undergoing total gastrectomy. The OS rates were significantly lower in the PNI-low group than in the PNI-high group among patients with stages II and III disease. We suggest that PNI is a simple and useful marker not only to identify patients at increased risk for postoperative complications, but also to predict long-term survival after total gastrectomy.