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World J Gastroenterol. Aug 14, 2014; 20(30): 10457-10463
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10457
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10457
Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis
Xiao-Hua Zhang, Min-Li Li, Bin Wang, Mei-Xia Guo, Ren-Min Zhu, Department of Gastroenterology, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
Author contributions: Zhang XH designed the study and wrote the paper; Li ML and Wang B performed the research; Guo MX and Zhu RM contributed analytic tools.
Supported by Funding from Jinling Hospital
Correspondence to: Dr. Xiao-Hua Zhang, Department of Gastroenterology, Jinling Hospital, 305 Zhongshan Donglu, Nanjing 210002, Jiangsu Province, China. jszhxh@sina.com
Telephone: +86-25-80860027 Fax: +86-25-80860127
Received: August 28, 2013
Revised: November 4, 2013
Accepted: May 28, 2014
Published online: August 14, 2014
Revised: November 4, 2013
Accepted: May 28, 2014
Published online: August 14, 2014
Core Tip
Core tip: Activation of caspase-1/interleukin (IL)-1β-converting-enzyme (ICE) and the over-production of IL-18 and IL-1β in the kidney play a pivotal role during the process of acute renal injury in severe acute pancreatitis. Furthermore, ICE inhibitors are effective in improving renal function. The mechanisms of ICE inhibition may be associated with descended cytokine mediated injury and decreased renal cell apoptosis. Therefore, the study of the mechanism of acute renal injury in severe acute pancreatitis may help identify measures for the prevention and treatment, as well as supply novel information to further our understanding of systemic inflammatory response syndrome and multiple system organ failure.