Sachdeva A, Rawat S, Nagpal J. Efficacy of fermented milk and whey proteins in Helicobacter pylori eradication: A review. World J Gastroenterol 2014; 20(3): 724-737 [PMID: 24574746 DOI: 10.3748/wjg.v20.i3.724]
Corresponding Author of This Article
Dr. Jitender Nagpal, Consultant, Department of Pediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi 110016, India. jitendernagpal@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
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World J Gastroenterol. Jan 21, 2014; 20(3): 724-737 Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.724
Efficacy of fermented milk and whey proteins in Helicobacter pylori eradication: A review
Aarti Sachdeva, Swapnil Rawat, Jitender Nagpal
Aarti Sachdeva, Swapnil Rawat, Department of Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi 110016, India
Jitender Nagpal, Department of Pediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi 110016, India
Author contributions: Nagpal J conceived the idea of the manuscript; Sachdeva A and Rawat S conducted the literature search, rated the studies and drafted the manuscript; Nagpal J finalized the manuscript and will act as guarantor for the paper.
Supported by Intramural funding by Sitaram Bhartia Institute of Science and Research, New Delhi
Correspondence to: Dr. Jitender Nagpal, Consultant, Department of Pediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi 110016, India. jitendernagpal@gmail.com
Telephone: +91-11-42111111 Fax: +91-11-26533027
Received: June 29, 2013 Revised: November 9, 2013 Accepted: December 5, 2013 Published online: January 21, 2014 Processing time: 234 Days and 24 Hours
Core Tip
Core tip: Treatment regimens for Helicobacter are cumbersome, prone to side effects and often have low success rates. Fermented milk and related proteins have often been explored as potential candidates for complementary therapy. The current review sought to summarize the current evidence available on their role in Helicobacter pylori eradication and found substantial evidence to support the use of fermented milk based probiotic preparation and bovine lactoferrin. Evidence for other whey proteins is preliminary and requires substantiation. Further work is necessary to identify the optimal substrate, fermentation process, dose and the ideal clinical setting. The potential of this group in antibiotic resistance or treatment failure settings also presents interesting possibilities.
