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World J Gastroenterol. Aug 7, 2014; 20(29): 10094-10107
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10094
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10094
RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer
Wei-Ling He, Shi-Rong Cai, Wu Song, Chang-Hua Zhang, Yu-Long He, Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Yu-Huang Li, Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, United States
Wei-Jian Hou, Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Zun-Fu Ke, Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Xin-Lin Chen, College of Fundamental Medical Science, Guangzhou University of Chinese Medicine, Guangzhou Higher Education Mega Center, Guangzhou 510006, Guangdong, China
Li-Ya Lu, Public Health, Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 8RZ, United Kingdom
Author contributions: He WL and Li YH designed research; He WL, Hou WJ and Zhang CH performed research; Ke ZF, Cai SR and He YL contributed new reagents or analytic tools; Hou WJ, Chen XL and Song W analyzed data; He WL, Li YH and Lu LY wrote the paper; He WL, Li YH and Hou WJ contributed equally to this work.
Supported by National Natural Science Foundation of China, No. 30973395, No. 81172337, No. 31271444 and No. 81201726; Municipal Medicine Science and Technology Foundation of Guangzhou, No. 201102A212012; Science and Technology Development Program of Guangdong, No. 2012B031800115; and Science Novel Program of Guangdong Education Department, No. A2003165
Correspondence to: Yu-Long He, Professor, Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Binjiang Rd, Guangzhou 510080, Guangdong Province, China. hylsums@hotmail.com
Telephone: +86-20-87755766 Fax: +86-20-87331059
Received: December 28, 2013
Revised: January 20, 2014
Accepted: March 6, 2014
Published online: August 7, 2014
Revised: January 20, 2014
Accepted: March 6, 2014
Published online: August 7, 2014
Core Tip
Core tip: This is the first study to show that PCI-24781 synergizes with the chemotherapeutic effect of cis-diamminedichloroplatinum in gastric cancer in vivo and in vitro, and PCI-24781-induced RAD51 repression may be one of the mechanisms. PCI-24781 could be a potential drug and novel therapeutic strategy for the treatment of gastric cancer.